1. A dual-acting 5-HT
- Author
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Vittorio, Canale, Katarzyna, Grychowska, Rafał, Kurczab, Mateusz, Ryng, Abdul Raheem, Keeri, Grzegorz, Satała, Agnieszka, Olejarz-Maciej, Paulina, Koczurkiewicz, Marcin, Drop, Klaudia, Blicharz, Kamil, Piska, Elżbieta, Pękala, Paulina, Janiszewska, Martyna, Krawczyk, Maria, Walczak, Severine, Chaumont-Dubel, Andrzej J, Bojarski, Philippe, Marin, Piotr, Popik, and Paweł, Zajdel
- Subjects
Male ,Indoles ,Monoamine Oxidase Inhibitors ,Drug Inverse Agonism ,Molecular Structure ,Rats, Sprague-Dawley ,Structure-Activity Relationship ,HEK293 Cells ,Neuroprotective Agents ,Alkynes ,Astrocytes ,Cell Line, Tumor ,Receptors, Serotonin ,Animals ,Humans ,Serotonin Antagonists ,Rats, Wistar ,Nootropic Agents - Abstract
The complex etiology of Alzheimer's disease has initiated a quest for multi-target ligands to address the multifactorial causes of this neurodegenerative disorder. In this context, we designed dual-acting 5-HT
- Published
- 2020