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Your search keyword '"Cupini, L M"' showing total 3 results
Start Over Author "Cupini, L M" Journal european journal of neurology
3 results on '"Cupini, L M"'

2. Early management of patients with medication‐overuse headache: results from a multicentre clinical study.

Author

Corbelli, I., Sarchielli, P., Eusebi, P., Cupini, L. M., Caproni, S., Calabresi, P., and SAMOHA Study Group

Subjects
MEDICATION abuse, HEADACHE treatment, HEADACHE, MIGRAINE, DRUG overdose, PATIENTS
Abstract

Background and purpose: Educational intervention has proved to be effective in reducing drug abuse in uncomplicated medication‐overuse headache (MOH). This ancillary of the SAMOHA multicentre study aimed to assess any differences in phenotypic characteristics, type and amount of drugs overused, and comorbidities between patients with MOH who responded to simple advice and those who did not. Methods: Demographic and clinical headache data of the last 3 months before enrollment of patients were collected and patients were then asked to fill out a daily headache diary for 4 weeks. Patients were then divided into two subgroups, i.e. those with confirmed MOH continued in the study [randomized (R) group], whereas those who did not still show any features of MOH dropped out of the study. Results: A total of 88 (67.7%) patients still met the inclusion criteria after the baseline 4 weeks (R group). Conversely, 42 (32.3%) patients dropped out of the study. A detailed analysis of those who dropped out revealed that only 34 were not randomized at visit 2 because they no longer satisfied the inclusion criteria for MOH [screening failures (SF) group]. The SF group was significantly younger and had fewer years of migraine history than the R group. Moreover, the SF group had a significantly shorter history of chronicity compared with the R group. Conclusions: Our findings suggest that in MOH trials, after an educational session, an observational period is needed in order to confirm the diagnosis of MOH and to avoid overestimation of the effect of other treatments used to manage MOH. Future research should focus mainly on those patients with MOH who do not respond to simple advice and with unsuccessful withdrawal. [ABSTRACT FROM AUTHOR]

Published
2018
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3. Psychopathological comorbidities in medication-overuse headache: a multicentre clinical study

Author

P, Sarchielli, I, Corbelli, P, Messina, L M, Cupini, G, Bernardi, G, Bono, V, Di Piero, B, Petolicchio, P, Livrea, M P, Prudenzano, L A, Pini, G, Sandrini, M, Allena, G, Tedeschi, A, Russo, S, Caproni, E, Beghi, P, Calabresi, Cinzia, Zandrini, Sarchielli, P, Corbelli, I, Messina, P, Cupini, L. M, Bernardi, G, Bono, G, Di Piero, V, Petolicchio, B, Livrea, P, Prudenzano, M. P, Pini, L. A, Sandrini, G, Allena, M, Tedeschi, Gioacchino, Russo, Antonio, Caproni, S, Beghi, E, and Calabresi, P.

Subjects
case-control studies, headache, medication-overuse headache, migraine, obsessive−compulsive disturbances, psychiatric disorders, 0301 basic medicine, Adult, Male, medicine.medical_specialty, obsessive compulsive disturbances, Beck Anxiety Inventory, Migraine Disorders, Comorbidity, medication overuse, 03 medical and health sciences, case control studies, 0302 clinical medicine, Internal medicine, Headache Disorders, Secondary, Prevalence, Medicine, Humans, Psychiatry, Mini-international neuropsychiatric interview, business.industry, Mental Disorders, Beck Depression Inventory, Middle Aged, medicine.disease, obsessive−compulsive disturbance, 030104 developmental biology, Mood, Neurology, Migraine, Anxiety, Female, Neurology (clinical), medicine.symptom, business, case-control studie, 030217 neurology & neurosurgery, Psychopathology
Abstract

Background and purpose In medication-overuse headache (MOH) patients, the presence of psychopathological disturbances may be a predictor of relapse and poor response to treatment. This multicentre study aimed to assess the occurrence of psychopathological disorders in MOH patients by comparing the incidence of psychopathological disturbances with episodic migraine (EM) patients and healthy controls (HC). Methods The psychopathological assessment of patients and HC involved the administrations of the Beck Depression Inventory, the Beck Anxiety Inventory, the Modified Mini International Neuropsychiatric Interview (M-MINI), the Yale−Brown Obsessive Compulsive Scale (Y-BOCS) and the Leeds Dependence Questionnaire. Results The MOH, EM and HC groups (88, 129 and 102 subjects, respectively) differed significantly from each other for the presence of moderate/severe anxiety, whereas mood disorder and depression were revealed in similar proportions for both MOH and EM patients. By stratifying the M-MINI questionnaire results according to the number of psychiatric disorders, it was found that MOH patients had a more complex profile of psychiatric comorbidity. Furthermore, clinically relevant obsessive−compulsive disturbances for abused drugs assessed by Y-BOCS appeared to be more represented in the MOH group, whilst the prevalence of this trait in the EM group was comparable to that of HC (12.5%, 0.8% and 0%, respectively). Conclusions Our study indicates the multiple presence of psychopathological comorbidities in patients with MOH. In light of this, it is recommended that the assessment of the psychopathological profile be included in an evaluation of MOH patients, allowing the clinician to more rapidly start an appropriate behavioural treatment, which would greatly improve MOH management.

Published
2015

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