Draak, T. H. P., Gorson, K. C., Vanhoutte, E. K., Nes, S. I., Doorn, P. A., Cornblath, D. R., Berg, L. H., Faber, C. G., Merkies, I. S. J., Barreira, A.A, Bennett, D, Van den Bergh, P.Y.K, Bombelli, F, Bril, V, Campanella, A, Cats, E.A, Costa, R, Devigili, G, Franques, J, and Gallia, F
Background and purpose There is increasing interest in using patient-reported outcome measures ( PROMs) in clinical studies to capture individual changes over time. However, PROMs have also been criticized because they are entirely subjective. Our objective was to examine the relationship between a subjective PROM and an objective outcome tool in patients with Guillain-Barré syndrome ( GBS), chronic inflammatory demyelinating polyradiculoneuropathy ( CIDP) and gammopathy-related polyneuropathy ( MGUSP). Methods The Inflammatory Rasch-built Overall Disability Scale (I- RODS©, a multi-item scale that examines functionality) was completed by 137 patients with newly diagnosed (or relapsing) GBS (55), CIDP (59) and MGUSP (23) who were serially examined ( GBS/ CIDP, T0/T1/T3/T6/T12 months; MGUSP, T0/T3/T12). Possible association between the I- RODS findings and the vigorimeter scores, an objective linear instrument to assess grip strength, was examined. Results A significant correlating trend was found between the I- RODS and grip strength scores for the overall group and in each illness, independently. Conclusion The objectivity of patients' subjective report on their functional state based on a strong correlation between the I- RODS and grip strength in patients with GBS, CIDP and MGUSP has been demonstrated. These findings provide further support to use the I- RODS and grip strength in future clinical studies in these conditions. [ABSTRACT FROM AUTHOR]