1. Chiasmatic lesions on conventional magnetic resonance imaging during the first event of optic neuritis in patients with neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein-associated disease in a Latin American cohort
- Author
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Alejandro Caride, Edgar Patricio Correa-Díaz, Enrique Gomez-Figueroa, Juan Pablo Pettinicchi, Edgardo Cristiano, Ricardo Alonso, Elisa Bribiesca Contreras, Vanessa Daccach Marques, Jefferson Santiago Piedra Andrade, Ibis Soto de Castillo, Marco Aurélio Lana-Peixoto, Juan Ignacio Rojas, María Angelica Ortiz Yepez, José Flores-Rivera, Juan Criniti, Lorna Galleguillos, Verónica Tkachuk, Edgar Carnero Contentti, Liliana Patrucco, Ana María Toral Granda, Debora Nadur, Pablo López, Magdalena Casas, Leila Cohen, and Wilson Alfredo Gualotuña Pachacama
- Subjects
medicine.medical_specialty ,Optic Neuritis ,Gastroenterology ,Myelin oligodendrocyte glycoprotein ,Myelin ,Internal medicine ,medicine ,Humans ,Optic neuritis ,Autoantibodies ,Aquaporin 4 ,Neuromyelitis optica ,Expanded Disability Status Scale ,biology ,medicine.diagnostic_test ,business.industry ,Neuromyelitis Optica ,Magnetic resonance imaging ,medicine.disease ,Magnetic Resonance Imaging ,medicine.anatomical_structure ,Latin America ,Neurology ,Cohort ,biology.protein ,Optic nerve ,Myelin-Oligodendrocyte Glycoprotein ,Neurology (clinical) ,business - Abstract
BACKGROUND AND PURPOSE Optic neuritis (ON) is often the initial symptom of neuromyelitis optica spectrum disorder (NMOSD) and myelin oligodendrocyte glycoprotein-associated disease (MOGAD). We aimed to compare the frequency and pattern of chiasmatic lesions in MOGAD-related ON (MOGAD-ON) and NMOSD-related ON (NMOSD-ON) using conventional brain imaging (magnetic resonance imaging [MRI]) in Latin America (LATAM). METHODS We reviewed the medical records and brain MRI (≤30 days from ON onset) of patients with a first event of MOGAD-ON and NMOSD-ON. Patients from Argentina (n = 72), Chile (n = 21), Ecuador (n = 31), Brazil (n = 30), Venezuela (n = 10) and Mexico (n = 82) were included. Antibody status was tested using a cell-based assay. Demographic, clinical, imaging and prognostic (as measured by the Visual Functional System Score [VFSS] of the Expanded Disability Status Scale) data were compared. RESULTS A total of 246 patients (208 NMOSD and 38 MOGAD) were included. No differences were found in gender and ethnicity between the groups. We observed chiasmatic lesions in 66/208 (31.7%) NMOSD-ON and in 5/38 (13.1%) MOGAD-ON patients (p = 0.01). Of these patients with chiasmatic lesions, 54/66 (81.8%) and 4/5 had associated longitudinally extensive optic nerve lesions, 45/66 (68%) and 4/5 had bilateral lesions, and 31/66 (47%) and 4/5 showed gadolinium-enhancing chiasmatic lesions, respectively. A positive correlation was observed between VFSS and presence of bilateral (r = 0,28, p
- Published
- 2021