1. Differentiation of malignant and degenerative bone lesions using dexamethasone interventional 3- and 24-hour bone scintigraphy.
- Author
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Bhatnagar A, Mondal A, Kashyap R, Sharma RK, Sharma R, Chakravarty SK, Bihari V, Sawroop K, Chopra MK, and Soni NL
- Subjects
- Bone and Bones diagnostic imaging, Diagnosis, Differential, Female, Humans, Male, Middle Aged, ROC Curve, Radionuclide Imaging, Sensitivity and Specificity, Technetium Tc 99m Medronate, Time Factors, Bone Diseases diagnostic imaging, Bone Neoplasms diagnostic imaging, Bone Neoplasms secondary, Dexamethasone administration & dosage
- Abstract
Seventy-seven adult patients with suspected skeletal metastases were divided into two groups. In group A (n = 30), following intravenous administration of 20 mCi (740 MBq) of technetium-99m methylene diphosphonate (99mTc-MDP), 3- and 24-h scintigraphy of bone lesions was performed. The 24/3 h lesion to bone background radiouptake ratio (RUR) was calculated for each lesion. In group B (n = 47), the same procedure was followed with dexamethasone intervention (10 mg in 24 h) following the 3-h acquisition. In group A, after determination of the critical point, malignant and degenerative bone lesions could be separated with a sensitivity, specificity and accuracy of 0.76, 0.72 and 0.73, respectively. The mean RUR of the malignant lesions was 1.20 +/- 0.23, and that of the benign lesions, 0.95 +/- 0.15. In group B cases, significantly increased sensitivity, specificity and accuracy of 0.87, 0.94 and 0.92, respectively, were found (P < 0.001). The mean RUR of the malignant lesions was 1.48 +/- 0.34, and that of degenerative lesions, 0.88 +/- 0.19. Dexamethasone interventional bone scintigraphy seems to be a new cost-effective method for differentiating malignant from degenerative bone lesions using the RUR.
- Published
- 1994
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