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Your search keyword '"Valtorta, S."' showing total 3 results
Start Over Author "Valtorta, S." Journal european journal of nuclear medicine and molecular imaging
3 results on '"Valtorta, S."'

2. Characterization of preclinical models of prostate cancer using PET-based molecular imaging

Author

Silvia Valtorta, Sara Belloli, Rodrigo Hess Michelini, Maria Picchio, Matteo Bellone, Massimo Freschi, Rosa Maria Moresco, Elena Jachetti, Ferruccio Fazio, Michela Lecchi, Belloli, S, Jachetti, E, Moresco, R, Picchio, M, Lecchi, M, Valtorta, S, Freschi, M, Hess Michelini, R, Bellone, M, Fazio, F, Moresco, Rm, Michelini, Rh, and Fazio, F.

Subjects
Male, Pathology, medicine.medical_specialty, Transgene, Mice, Transgenic, urologic and male genital diseases, Choline, chemistry.chemical_compound, Prostate cancer, Mice, In vivo, Fluorodeoxyglucose F18, Cell Line, Tumor, medicine, Animals, Humans, Radiology, Nuclear Medicine and imaging, Carbon Radioisotopes, Neoplasm Staging, TRAMP mouse, medicine.diagnostic_test, business.industry, Prostatic Neoplasms, Reproducibility of Results, Biological Transport, General Medicine, medicine.disease, Hormones, Mice, Inbred C57BL, Disease Models, Animal, PET, chemistry, Positron emission tomography, Positron-Emission Tomography, Disease Progression, Adenocarcinoma, [11C]Choline, [18F]FDG, Molecular imaging, business, Tramp
Abstract

PURPOSE: Transgenic adenocarcinoma of the mouse prostate (TRAMP) mice spontaneously develop hormone-dependent and hormone-independent prostate cancer (PC) that potentially resembles the human pathological condition. The aim of the study was to validate PET imaging as a reliable tool for in vivo assessment of disease biology and progression in TRAMP mice using radioligands routinely applied in clinical practice: [(18)F]FDG and [(11)C]choline. METHODS: Six TRAMP mice were longitudinally evaluated starting at week 11 of age to visualize PC development and progression. The time frame and imaging pattern of PC lesions were subsequently confirmed on an additional group of five mice. RESULTS: PET and [(18)F]FDG allowed detection of PC lesions starting from 23 weeks of age. [(11)C]Choline was clearly taken up only by TRAMP mice carrying neuroendocrine lesions, as revealed by post-mortem histological evaluation. CONCLUSION: PET-based molecular imaging represents a state-of-the-art tool for the in vivo monitoring and metabolic characterization of PC development, progression and differentiation in the TRAMP model

Published
2008

3. Characterization of preclinical models of prostate cancer using PET-based molecular imaging.

Author

Belloli S, Jachetti E, Moresco RM, Picchio M, Lecchi M, Valtorta S, Freschi M, Hess Michelini R, Bellone M, and Fazio F

Subjects
Animals, Biological Transport, Carbon Radioisotopes chemistry, Cell Line, Tumor, Choline chemistry, Choline metabolism, Disease Models, Animal, Disease Progression, Fluorodeoxyglucose F18 metabolism, Hormones metabolism, Humans, Male, Mice, Mice, Inbred C57BL, Mice, Transgenic, Neoplasm Staging, Positron-Emission Tomography, Prostatic Neoplasms metabolism, Prostatic Neoplasms pathology, Reproducibility of Results, Prostatic Neoplasms diagnostic imaging
Abstract

Purpose: Transgenic adenocarcinoma of the mouse prostate (TRAMP) mice spontaneously develop hormone-dependent and hormone-independent prostate cancer (PC) that potentially resembles the human pathological condition. The aim of the study was to validate PET imaging as a reliable tool for in vivo assessment of disease biology and progression in TRAMP mice using radioligands routinely applied in clinical practice: [(18)F]FDG and [(11)C]choline., Methods: Six TRAMP mice were longitudinally evaluated starting at week 11 of age to visualize PC development and progression. The time frame and imaging pattern of PC lesions were subsequently confirmed on an additional group of five mice., Results: PET and [(18)F]FDG allowed detection of PC lesions starting from 23 weeks of age. [(11)C]Choline was clearly taken up only by TRAMP mice carrying neuroendocrine lesions, as revealed by post-mortem histological evaluation., Conclusion: PET-based molecular imaging represents a state-of-the-art tool for the in vivo monitoring and metabolic characterization of PC development, progression and differentiation in the TRAMP model.

Published
2009
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