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Your search keyword '"Verzijlbergen, J. Fred"' showing total 4 results
Start Over Author "Verzijlbergen, J. Fred" Journal european journal of nuclear medicine and molecular imaging
4 results on '"Verzijlbergen, J. Fred"'

3. Comparison of technetium-99m sestamibi left ventricular wall motion and perfusion studies with thallium-201 perfusion imaging: in search of the combination of variables with the highest accuracy in predicting coronary artery disease

Author

Verzijlbergen, J. Fred, Zwinderman, Aelko H., Ascoop, Carl A. P. L., Wall, Ernst E., Niemeyer, Menco G., and Pauwels, Ernest K. J.

Abstract

Measurements of myocardial perfusion and ventricular function are expected to provide additional information in the detection of coronary artery disease (CAD). The purpose of this study was threefold: (1) to determine to what extent technetium-99m sestamibi wall motion yields different information compared with99mTc-sestamibi and thallium-201 perfusion; (2) to test which information unique to either study is of value in diagnosing CAD; and (3) to assess the combination of variables with the highest diagnostic accuracy. Perfusion and wall motion scores (at rest and during exercise) obtained from visual and quantitative planar201T1 and99mTc-sestamibi scintigraphy of 60 patients with suspected CAD were compared with the angiographic results by means of a polytomous logistic regression model and the diagnostic values were compared with one another. All univariate variables were significantly related to the probability of CAD and its extent. Comparative studies revealed a large degree of correlation between201T1 stress and redistribution variables. The rest99mTc-sestamibi and wall motion studies contained partially different information. Stepwise logistic regression analysis showed the strongest diagnostic power for the combination of201Tl visual analysis of the stress images with quantitative redistribution images (sensitivity 93%, specificity 71%). The diagnostic power was similar for all combinations of visual and quantitative analyses of the exercise and redistribution images. The strongest diagnostic power of the99mTc-sestamibi variables was the score of the diastolic stress image (sensitivity 91%, specificity 79%). Comparable sensitivity and specificity estimates were found when both optimal models were compared. Wall motion studies did not have additional diagnostic power. Although99mTc-sestamibi wall motion studies, both at rest and during exercise, provide information in addition to the99mTc-sestamibi or201Tl myocardial perfusion variables, the information does not enhance the diagnostic power with regard to the prediction of CAD.

Published
1996
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4. Incremental prognostic value of myocardial SPET with dual-isotope rest (201)Tl/stress (99m)Tc-tetrofosmin.

Author

Groutars RG, Verzijlbergen JF, Zwinderman AH, Tiel-Van Buul MM, Ascoop CA, van Hemel NM, and van der Wall EE

Subjects
Adult, Aged, Aged, 80 and over, Coronary Disease diagnosis, Coronary Disease mortality, Electrocardiography, Female, Heart diagnostic imaging, Humans, Male, Middle Aged, Multivariate Analysis, Prognosis, Proportional Hazards Models, Survival Analysis, Coronary Disease diagnostic imaging, Exercise Test, Organophosphorus Compounds, Organotechnetium Compounds, Radiopharmaceuticals, Thallium Radioisotopes, Tomography, Emission-Computed, Single-Photon
Abstract

The incremental prognostic value of dual-isotope myocardial perfusion scintigraphy using technetium-99m tetrofosmin for the stress images was evaluated in 597 consecutive patients with known or suspected coronary artery disease. We used semi-quantitative visual analysis with a five-point scoring system and calculated the summed stress score, the summed rest score and the summed difference score. During the 2-year follow-up period, 46 "hard" cardiac events occurred: 16 cardiac deaths and 30 non-fatal myocardial infarctions. Kaplan-Meier analysis demonstrated a favourable prognosis for patients with normal scans as compared with patients with mildly to moderately or severely abnormal scans ( P<0.001). Multivariate analysis demonstrated incremental prognostic information for nuclear variables. A very low rate of hard cardiac events was observed in patients with a low summed stress score. Thus, nuclear variables provide incremental prognostic information and could be used to guide the management process with respect to whether or not to proceed with further invasive procedures.

Published
2002
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