1. Association of dietary zinc intake with coronary artery calcium progression: the Multi-Ethnic Study of Atherosclerosis (MESA).
- Author
-
Gao, Jing-Wei, Zhang, Shao-Ling, Hao, Qing-Yun, Huang, Fei-Fei, Liu, Zhao-Yu, Zhang, Hai-Feng, Yan, Li, Wang, Jing-Feng, and Liu, Pin-Ming
- Subjects
- *
DISEASE progression , *CONFIDENCE intervals , *NUTRITIONAL assessment , *MEAT , *INGESTION , *RISK assessment , *CORONARY artery disease , *QUESTIONNAIRES , *DESCRIPTIVE statistics , *ZINC , *CORONARY arteries , *CALCIUM , *ETHNIC groups , *COMPUTED tomography , *LONGITUDINAL method - Abstract
Purpose: Zinc is considered protective against atherosclerosis; however, the association between dietary zinc intake and cardiovascular disease remains debated. We investigated whether dietary zinc intake was associated with coronary artery calcium (CAC) progression in the Multi-Ethnic Study of Atherosclerosis (MESA). Methods: This analysis included 5186 participants aged 61.9 ± 10.2 years (48.8% men; 41.3% white, 25.0% black, 21.6% Hispanic, and 12.1% Chinese American) from the MESA. Dietary zinc intake was assessed by a self-administered, 120-item food frequency questionnaire at baseline (2000–2002). Baseline and follow-up CAC were measured by computed tomography. CAC progression was defined as CAC > 0 at follow-up for participants with CAC = 0 at baseline; and an annualized change of 10 or percent change of ≥ 10% for those with 0 < CAC < 100 or CAC ≥ 100 at baseline, respectively. Results: Dietary zinc intake was 8.4 ± 4.5 mg/day and 2537 (48.9%) of the included participants had CAC at baseline. Over a median follow-up of 3.4 years (25th–75th percentiles = 2.0–9.1 years), 2704 (52.1%) participants had CAC progression. In the fully adjusted model, higher dietary zinc was associated with a lower risk of CAC progression in both men (hazard ratio [HR] 0.697, 95% confidence interval [CI] 0.553–0.878; p = 0.002) and women (HR 0.675; 95% CI 0.496–0.919; p = 0.012, both comparing extreme groups). Furthermore, such an inverse association was attributable to dietary zinc intake from non-red meat (p < 0.05), rather than red meat sources (p > 0.05). Conclusions: In this multiethnic population free of clinically apparent cardiovascular disease, higher dietary zinc intake from non-red meat sources was independently associated with a lower risk of CAC progression. Clinical trial registration number: The MESA trial was registered at clinicaltrials.gov as NCT00005487. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF