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Start Over Author "Galen J Correy" Journal european journal of organic chemistry
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1. Total Syntheses of the Amaryllidaceae Alkaloids Zephycandidine III and Lycosinine A and Their Evaluation as Inhibitors of Acetylcholinesterase

Author

Xing-Jun Xu, Galen J. Correy, Wei-Min Chen, Anthony C. Willis, Xiang Ma, Martin G. Banwell, Paul D. Carr, Colin J. Jackson, and Hye-Sun Kim

Subjects
chemistry.chemical_classification, endocrine system, 010405 organic chemistry, Stereochemistry, organic chemicals, Alkaloid, Organic Chemistry, 010402 general chemistry, Lycosinine, complex mixtures, 01 natural sciences, Acetylcholinesterase, 0104 chemical sciences, chemistry.chemical_compound, Enzyme, chemistry, Organic chemistry, heterocyclic compounds, Physical and Theoretical Chemistry, Amaryllidaceae Alkaloids
Abstract

The title alkaloids, 1 and 2 respectively, have been prepared using cross-coupling chemistries and together with various analogues they have been evaluated for their capacity to inhibit acetylcholinesterase. Contrary to an earlier report, we have found that biaryl 1 is not a significant inhibitor of this enzyme and nor are any of its congeners, including alkaloid 2.

Published
2017
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