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Your search keyword '"Grishchenko, Lyudmila A."' showing total 2 results
Start Over Author "Grishchenko, Lyudmila A." Journal european journal of organic chemistry
2 results on '"Grishchenko, Lyudmila A."'

2. Functionalized Hexahydropyrrolo[2,1-b]oxazoles from Catalyst-Free Annulation of Δ¹-Pyrrolines with Electron-Deficient Propargylic Alcohols.

Author

Oparina, Ludmila A., Shabalin, Dmitrii A., Mal'kina, Anastasiya G., Kolyvanov, Nikita A., Grishchenko, Lyudmila A., Ushakov, Igor' A., Vashchenko, Alexander V., and Trofimov, Boris A.

Subjects
ANNULATION, ALCOHOL, HETEROCYCLIC chemistry
Abstract

Electron-deficient propargylic alcohols (EWG = CN, C(O)Ph, CO2Me, C(O)NH2) under catalyst-free mild conditions are annulated with Δ1-pyrrolines to afford functionalized hexahydropyrrolo[ 2,1-b]oxazoles, mostly in 19–93 % yield. The synthesis is stereoselective with respect to disposition of functionalized ethenyl group relative to the condensed heterocyclic system thus formed in most cases. This methodology provides a simple one-pot access to a novel family of synthetically and pharmaceutically prospective. [ABSTRACT FROM AUTHOR]

Published
2020
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