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Start Over Author "Haruki Morimoto" Journal european journal of organic chemistry
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1. Catalytic Enantioselective Synthesis of Trisubstituted Secondary Allylic Alcohols Starting from Terminal Alkynes and Aldehydes

Author

Haruki Morimoto and Toshiro Harada

Subjects
Addition reaction, Allylic rearrangement, Nucleophilic addition, Chemistry, Reagent, Organic Chemistry, Enantioselective synthesis, Organic chemistry, Physical and Theoretical Chemistry, Catalysis
Abstract

A general one-pot method for the enantioselective synthesis of β,β-disubstituted allylic alcohols has been developed starting from readily available terminal alkynes and aldehydes. Trisubstituted (E)-vinylaluminium reagents, generated regio- and stereoselectively by the Zr-catalyzed carboalumination of the alkynes with Me3Al, was used in subsequent enantioselective addition reactions with aldehydes using a DPP-H8-BINOL-derived titanium catalyst system at low catalyst loading (5 mol-%).

Published
2015
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