1. Synthetic Approaches to Anti-Inflammatory Macrolactones of the Oxacyclododecindione Type
- Author
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Markus Rohr, Kristina Rudolph, Johannes Tauber, Till Opatz, and Gerhard Erkel
- Subjects
chemistry.chemical_classification ,Double bond ,Stereochemistry ,medicine.drug_class ,Organic Chemistry ,Hydroacylation ,Total synthesis ,Metathesis ,Ring (chemistry) ,Anti-inflammatory ,Ring-closing metathesis ,chemistry ,medicine ,Physical and Theoretical Chemistry ,Isomerization - Abstract
Various synthetic approaches to the oxacyclododecindione-type macrolactones, known for their potent anti-inflammatory activity, are presented. These include an attempted carbonylative ring closure, a hydroacylation route, and an approach by ring-closing metathesis and double bond isomerization, as well as a strategy including ring-closing metathesis/unsaturation. The last route allowed the preparation of a bioactive analogue of the recently described 14-deoxyoxacyclododecindione.
- Published
- 2015
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