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Start Over Author "Mayol, Laura" Journal european journal of pharmaceutics and biopharmaceutics
3 results on '"Mayol, Laura"'

3. Curcumin loaded PLGA–poloxamer blend nanoparticles induce cell cycle arrest in mesothelioma cells

Author

Antonina Saija, Marco Biondi, Simona Giarra, Maria Teresa Piccolo, Laura Mayol, Carla Serri, Stefania Crispi, Luigi Mita, Damiano Gustavo Mita, Maurizio Forte, Ciro Menale, Mayol, Laura, Carla, Serri, Menale, Ciro, Stefania, Crispi, Maria Teresa Piccolo, Luigi, Mita, Simona, Giarra, Maurizio, Forte, Antonina, Saija, Biondi, Marco, and Damiano Gustavo Mita

Subjects
Mesothelioma, inorganic chemicals, Curcumin, Surface Properties, Chemistry, Pharmaceutical, education, Pharmaceutical Science, Nanoparticle, Nanotechnology, Curcumin, Mesothelioma, Nanoparticles, PLGA, Poloxamers, Stealth, Poloxamer, macromolecular substances, Absorption (skin), Poloxamers, chemistry.chemical_compound, Drug Stability, Polylactic Acid-Polyglycolic Acid Copolymer, Cell Line, Tumor, Humans, Technology, Pharmaceutical, Lactic Acid, Particle Size, Stealth, health care economics and organizations, Cell Proliferation, Drug Carriers, Chemistry, technology, industry, and agriculture, PLGA, Cell Cycle Checkpoints, Drug Tolerance, General Medicine, Antineoplastic Agents, Phytogenic, Bioavailability, Kinetics, Nanomedicine, Solubility, Biophysics, Nanoparticles, Drug carrier, Polyglycolic Acid, Protein Binding, Biotechnology
Abstract

The pharmacological potential of curcumin (CURC) is severely restricted because of its low water solubility/absorption, short half-life and poor bioavailability. To overcome these issues, CURC-loaded nanoparticles (NPs) were produced by a double emulsion technique. In particular, NPs were made up of an amphiphilic blend of poloxamers and PLGA to confer stealth properties to the NPs to take advantage of the enhanced permeability and retention (EPR) effect. Different surface properties of NPs made up of bare PLGA and PLGA/poloxamer blend were confirmed by the different interactions of these NPs with serum proteins and also by their ability to be internalized by mesothelioma cell line. The uptake of PLGA/poloxamer NPs induces a persistent block in G0/G1 phase of the cell cycle up to 72 h, thus overcoming the drug tolerance phenomenon, normally evidenced with free CURC.

Published
2015
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