1. Different effects of dronedarone and amiodarone on pulmonary vein electrophysiology, mechanical properties and H2O2-induced arrhythmogenicity
- Author
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Shih Lin Chang, Yu Hsun Kao, Yi Jen Chen, Yung Kuo Lin, Yen Yu Lu, Shih Ann Chen, Yao Chang Chen, and Dicky Armein Hanafy
- Subjects
medicine.medical_specialty ,Diastole ,Amiodarone ,Vasodilation ,In Vitro Techniques ,Pulmonary vein ,Contractility ,Internal medicine ,medicine ,Animals ,Dronedarone ,Pharmacology ,Fibrillation ,business.industry ,Arrhythmias, Cardiac ,Atrial fibrillation ,Hydrogen Peroxide ,medicine.disease ,Electrophysiological Phenomena ,Oxidative Stress ,Pulmonary Veins ,Anesthesia ,cardiovascular system ,Cardiology ,Rabbits ,medicine.symptom ,business ,Anti-Arrhythmia Agents ,medicine.drug - Abstract
Dronedarone and amiodarone are anti-atrial fibrillation agents with different potency. Pulmonary veins play a critical role in the genesis of atrial fibrillation. Oxidative stress can enhance pulmonary vein arrhythmogenesis. This study was done to compare the effects of dronedarone and amiodarone on pulmonary vein electrophysiological and mechanical properties, and oxidative stress-induced arrhythmogenecity. Conventional microelectrodes were used to record action potentials in isolated rabbit pulmonary vein specimens before and after dronedarone and amiodarone with or without the presence of H2O2 (2mM). Dronedarone (0.1, 1 and 10 μM) concentration-dependently decreased pulmonary vein beating rates (from 2.2±0.1 to 1.9±0.1, 1.8±0.1 and 1.7±0.1Hz, n=8, P
- Published
- 2013
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