1. Effects of methylenedioxymethamphetamine on the release of monoamines from rat brain slices
- Author
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John L. Fitzgerald and Julianne J. Reid
- Subjects
Serotonin ,Dopamine ,N-Methyl-3,4-methylenedioxyamphetamine ,Hippocampus ,Pharmacology ,Norepinephrine ,mental disorders ,medicine ,Animals ,3,4-Methylenedioxyamphetamine ,Chemistry ,Rats, Inbred Strains ,MDMA ,Corpus Striatum ,Electric Stimulation ,Rats ,Monoamine neurotransmitter ,Mechanism of action ,Liberation ,Female ,medicine.symptom ,psychological phenomena and processes ,medicine.drug - Abstract
The effects of 3,4-methylenedioxymethamphetamine (MDMA) on monoamine release were investigated in superfused slices of rat striatum and hippocampus. MDMA (10 microM) increased the resting release of radioactivity from slices incubated in [3H]dopamine, [3H]5-hydroxytryptamine or [3H]noradrenaline. These effects of MDMA (10 microM) were blocked by the neuronal uptake inhibitors, cocaine (10 microM), fluoxetine (1 microM) and desmethylimipramine (1 microM), respectively. MDMA (10 microM) enhanced the stimulation-induced efflux of radioactivity from slices incubated in [3H]noradrenaline but not from slices incubated in [3H]5-hydroxytryptamine or [3H]dopamine. These results demonstrate for the first time a direct noradrenaline-releasing action of MDMA and differential effects of MDMA on the stimulation-induced release of noradrenaline, dopamine and 5-hydroxytryptamine from rat superfused brain slices.
- Published
- 1990