1. Coronary heart disease incidence in women by waist circumference within categories of body mass index
- Author
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Dexter, Canoy, Benjamin J, Cairns, Angela, Balkwill, F Lucy, Wright, Jane, Green, Gillian, Reeves, Valerie, Beral, and Matthew, Wallis
- Subjects
medicine.medical_specialty ,Time Factors ,Waist ,Epidemiology ,Coronary Disease ,Body Mass Index ,Sex Factors ,Risk Factors ,Internal medicine ,medicine ,Humans ,Prospective Studies ,Abdominal obesity ,Adiposity ,Aged ,Apolipoproteins B ,Proportional Hazards Models ,Waist-to-height ratio ,Apolipoprotein A-I ,Body volume index ,business.industry ,Incidence ,Incidence (epidemiology) ,Age Factors ,nutritional and metabolic diseases ,Middle Aged ,Prognosis ,medicine.disease ,Circumference ,Obesity ,United Kingdom ,Surgery ,Hospitalization ,Obesity, Abdominal ,Cardiology ,Female ,Waist Circumference ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business ,Body mass index ,Biomarkers - Abstract
High body mass index (BMI) and large waist circumference are separately associated with increased coronary heart disease (CHD) risk but these measures are highly correlated. Their separate associations with incident CHD, cross-classifying one variable by the other, are less investigated in large-scale studies. We examined these associations in a large UK cohort (the Million Women Study), which is a prospective population-based study. We followed 496,225 women (mean age 60 years) with both waist circumference and BMI measurements who had no vascular disease or cancer. Adjusted relative risk and 20-year cumulative CHD incidence (first coronary hospitalization or death) from age 55 to 74 years were calculated using Cox regression. Plasma apolipoproteins were assayed in 6295 randomly selected participants. There were 10,998 incident coronary events after mean follow up of 5.1 years. Within each BMI category (
- Published
- 2013
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