1. Potential role of combined FDG PET/CT & contrast enhancement MRI in a rectal carcinoma model with nodal metastases characterized by a poor FDG-avidity
- Author
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Farace, Paolo, Conti, Giamaica, Merigo, Flavia, Tambalo, Stefano, Marzola, Pasquina, Sbarbati, Andrea, Quarta, Carmelo, D’Ambrosio, Daniela, Chondrogiannis, Sotirios, Nanni, Cristina, and Rubello, Domenico
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RADIOPHARMACEUTICALS , *POSITRON emission tomography , *CONTRAST-enhanced magnetic resonance imaging , *RECTAL cancer , *METASTASIS , *LYMPH nodes , *IMMUNOHISTOCHEMISTRY - Abstract
Abstract: Purpose: To investigate the additional role of MRI contrast enhancement (CE) in the primary tumor and the FDG uptake at PET in the lymph-node metastases. Materials and methods: A model of colorectal cancer induced by orthotopic HT-29 cells microinjection, producing pelvic lymph node metastases, was assessed using CE-MRI and FDG-PET. Histology and GLUT-1 immunohistochemistry were performed on primary tumors and iliac lymph nodes. Results: Primary tumors were characterized by low FDG-uptake but high CE-MRI, particularly at tumor periphery. Undetectable FDG-uptake characterized the metastatic lymph-nodes. Histology revealed large stromal bundles at tumor periphery and a dense network of stromal fibers and neoplastic cells in the inner portion of the tumors. Both primary tumors and positive lymph nodes showed poor GLUT-1 staining. Conclusion: Our data support the complementary role of MRI-CE and FDG PET in some types of carcinomas characterized by abundant cancer-associated stroma and poor FDG avidity consequent to poor GLUT-1 transported. In these tumors FDG-PET alone may be not completely adequate to obtain an adequate tumor radiotherapy planning, and a combination with dual CE-MRI is strongly recommended. [Copyright &y& Elsevier]
- Published
- 2012
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