1. The regional myocardial microvascular dysfunction differences in hypertrophic cardiomyopathy patients with or without left ventricular outflow tract obstruction: Assessment with first-pass perfusion imaging using 3.0-T cardiac magnetic resonance.
- Author
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Xu, Hua-yan, Yang, Zhi-gang, Sun, Jia-yu, Wen, Ling-yi, Zhang, Ge, Zhang, Shuai, and Guo, Ying-kun
- Subjects
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MICROCIRCULATION disorders , *HYPERTROPHIC cardiomyopathy , *LEFT heart ventricle , *VENTRICULAR outflow obstruction , *CARDIAC magnetic resonance imaging , *IMAGE analysis , *COMPARATIVE studies , *PATIENTS - Abstract
Abstract: Purpose: To assess regional myocardial microvascular dysfunction differences in hypertrophic cardiomyopathy (HCM) patients with or without left ventricular outflow tract obstruction using 3.0-T cardiac magnetic resonance (CMR) first-pass perfusion imaging. Materials and methods: Forty-two HCM patients, including 25 HCM patients with left ventricular outflow tract obstruction (HOCM), 17 HCM patients without left ventricular outflow tract obstruction (NOHCM), and 14 healthy subjects underwent CMR. The left ventricular (LV) function, left ventricular end-diastolic wall thickness (EDTH), and diameter of left ventricular outflow tract (LVOT) were measured and calculated. Based on the signal–time curve of the first-pass myocardium perfusion imaging, perfusion parameters including upslope, time to peak, and peak intensity, were assessed and compared by using one-way analysis of variance and independent t tests. Results: On the first-pass perfusion imaging, lower upslope and peak intensity and longer time to peak were found in HCM patients compared with normal subjects (all p <0.05). In contrast to the NOHCM group, the average time to peak of the HOCM group was increased (13.30±4.82s vs 16.28±4.90s, p <0.05), but first-pass perfusion upslope was reduced (4.96±2.55 vs 2.58±0.77, p <0.05). According to the bull's-eye model, the HOCM group's average thickness of basal segments was thicker than the NOHCM group, especially the anteroseptal, inferolateral, and anterior wall values, with a corresponding lower first-pass perfusion upslope than the NOHCM group (all p <0.05). A significant correlation was observed between first-pass perfusion upslope and LV EDTH (r =−0.551, p <0.001) and LVOT diameter (r =0.472, p <0.001). Conclusions: The regional myocardial microvascular dysfunction differences in hypertrophic cardiomyopathy (HCM) patients with or without left ventricular outflow tract obstruction can be detected with first-pass perfusion CMR imaging. [Copyright &y& Elsevier]
- Published
- 2014
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