1. Local immunoglobulin synthesis and blood-brain barrier assessment in subacute sclerosing panencephalitis
- Author
-
Carlos Alberto Silva, Celso Cruz, and Maria Edite Rio
- Subjects
Adult ,Male ,Pathology ,medicine.medical_specialty ,Adolescent ,Central nervous system ,Immunoglobulins ,Immunoglobulin E ,Blood–brain barrier ,Subacute sclerosing panencephalitis ,medicine ,Humans ,alpha-Macroglobulins ,Child ,Serum Albumin ,biology ,medicine.disease ,Immunoglobulin A ,medicine.anatomical_structure ,Neurology ,Blood-Brain Barrier ,Immunoglobulin G ,Immunology ,biology.protein ,Neurology (clinical) ,Viral disease ,Subacute Sclerosing Panencephalitis ,Antibody - Abstract
The immunoglobulin synthesis within the central nervous system and the blood-brain barrier (BBB) function were evaluated in 6 patients with subacute sclerosing panencephalitis (SSPE) using the IgG index and a graphic method based on serum/CSF albumin, alpha 2-macroglobulin, and IgG quotients. A strong local production of IgG was documented by both methods in all 6 cases of SSPE. Concerning the graphic analysis, the decrease in the serum/CSF alpha 2-macroglobulin ratio disclosed BBB dysfunction in 2 cases of SSPE, suggesting, in the absence of the serum/CSF albumin quotient abnormalities, that a homeostatic mechanism for CSF proteins can cause changes in the CSF protein profile.
- Published
- 1985