1. Regional Specific Changes of Cerebral Metabolism in Systemic Lupus erythematosus Identified by Positron Emission Tomography
- Author
-
AH van Zomeren, K.D. Beintema, H Haaxma-Reiche, P. E. Spronk, Cornelis Kallenberg, Jan Pruim, L.G.F. Sinnige, de Bauke Jong, and Hendrika Bootsma
- Subjects
Adult ,Male ,medicine.medical_specialty ,Pathology ,Adolescent ,Central nervous system ,Statistical parametric mapping ,Premotor cortex ,Pathogenesis ,Fluorodeoxyglucose F18 ,Internal medicine ,Basal ganglia ,medicine ,Humans ,Lupus Erythematosus, Systemic ,Lupus erythematosus ,medicine.diagnostic_test ,business.industry ,Brain ,Middle Aged ,medicine.disease ,Connective tissue disease ,medicine.anatomical_structure ,Endocrinology ,Neurology ,Regional Blood Flow ,Positron emission tomography ,Female ,Neurology (clinical) ,business ,Tomography, Emission-Computed - Abstract
In order to test the hypothesis whether the pathogenesis of cerebral systemic lupus erythematosus (SLE) may include an immune-mediated deficit in specific vulnerable brain regions, the regional cerebral metabolism in 9 patients with diffuse as well as focal cerebral symptoms was compared with that of 10 age-matched control subjects. The cerebral distribution of 2-[18F]fluoro-2-deoxy-D-glucose (FDG) uptake was measured by means of positron emission tomography. Subsequently performed statistical parametric mapping showed (i) a relative increase in metabolism in the striatum and (ii) regional decreases in the premotor cortex as a common feature in the patient group. Region of interest measurements of absolute FDG uptake confirmed these findings. The increased striatal activity may support the presence of a direct immune response against neuronal tissue in SLE, similar to the cross-reaction against inhibitory components in striatal tissue provoked by streptococcal antigens.
- Published
- 1999