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This paper analyses the effects that mobility restrictions during the COVID-19 pandemic have had on different types of co-presence, which the existing literature considers to be central for science and innovation. Drawing on a regional analysis of COVID-19 restrictions in Germany, it links specific mobility restrictions to concrete impacts on co-presence, differentiating between co-presence in organizations, dynamic temporary co-presence, and the local 'buzz'. It highlights that co-presence at workplaces and conferences was resilient to restrictions but that the detrimental effects on the 'local buzz' may have been substantial and long-lasting. In conclusion, it cautions against the severe effects of placing restrictions on the education system. Subsequently, the discussion links the reported disruptions of co-presence to the potential effects of the pandemic on preconditions for innovative processes and economic recovery. [ABSTRACT FROM AUTHOR]