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Developed essentially in the context of American cities, the Transit Oriented Development (TOD) model has also occupied the literature regarding European cities, especially those with long developed urban rail systems. This paper provides a critical overview of the TOD model regarding three main topics: key features and typologies; benefits, drawbacks and implementation challenges; and readiness criteria. It then proceeds to an investigation of the potential for implementing the TOD model in the context of Southern European cities, traditionally considered to fall into typical compact forms of development, many of which also lack integrated urban and transport planning. Based on the case of Thessaloniki, Greece, which introduces urban rail by constructing a metro system, a typology is proposed, adapted to the case of a dense and mixed-use city, and two pilot TOD plans are presented. The paper highlights that an integrated urban and transport planning based on a modification of the TOD model could be implemented in Southern European cities, taking advantage of their compact and mixed-use features but also constraining the relatively recent phenomenon of suburban dispersion. Nevertheless, overcoming the multiple institutional and financing barriers is necessary to guarantee a successful transfer and adaptation of the TOD model. [ABSTRACT FROM AUTHOR]