1. Noninvasive electrical conductivity measurement by MRI: a test of its validity and the electrical conductivity characteristics of glioma.
- Author
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Tha KK, Katscher U, Yamaguchi S, Stehning C, Terasaka S, Fujima N, Kudo K, Kazumata K, Yamamoto T, Van Cauteren M, and Shirato H
- Subjects
- Adolescent, Adult, Aged, Aged, 80 and over, Brain diagnostic imaging, Brain pathology, Brain Neoplasms diagnostic imaging, Child, Female, Glioma diagnostic imaging, Humans, Imaging, Three-Dimensional methods, Male, Middle Aged, Reproducibility of Results, Retrospective Studies, Young Adult, Brain Neoplasms pathology, Electric Conductivity, Glioma pathology, Magnetic Resonance Imaging methods
- Abstract
Objectives: This study noninvasively examined the electrical conductivity (σ) characteristics of diffuse gliomas using MRI and tested its validity., Methods: MRI including a 3D steady-state free precession (3D SSFP) sequence was performed on 30 glioma patients. The σ maps were reconstructed from the phase images of the 3D SSFP sequence. The σ histogram metrics were extracted and compared among the contrast-enhanced (CET) and noncontrast-enhanced tumour components (NCET) and normal brain parenchyma (NP). Difference in tumour σ histogram metrics among tumour grades and correlation of σ metrics with tumour grades were tested. Validity of σ measurement using this technique was tested by correlating the mean tumour σ values measured using MRI with those measured ex vivo using a dielectric probe., Results: Several σ histogram metrics of CET and NCET of diffuse gliomas were significantly higher than NP (Bonferroni-corrected p ≤ .045). The maximum σ of NCET showed a moderate positive correlation with tumour grade (r = .571, Bonferroni-corrected p = .018). The mean tumour σ measured using MRI showed a moderate positive correlation with the σ measured ex vivo (r = .518, p = .040)., Conclusions: Tissue σ can be evaluated using MRI, incorporation of which may better characterise diffuse gliomas., Key Points: • This study tested the validity of noninvasive electrical conductivity measurements by MRI. • This study also evaluated the electrical conductivity characteristics of diffuse glioma. • Gliomas have higher electrical conductivity values than the normal brain parenchyma. • Noninvasive electrical conductivity measurement can be helpful for better characterisation of glioma.
- Published
- 2018
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