23 results on '"Alain Luciani"'
Search Results
2. MRI features associated with HCC histologic subtypes: a western American and European bicenter study
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Sébastien Mulé, Ali Serhal, Athena Galletto Pregliasco, Jessica Nguyen, Camila Lopes Vendrami, Edouard Reizine, Guang-Yu Yang, Julien Calderaro, Giuliana Amaddeo, Alain Luciani, and Frank H. Miller
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Radiology, Nuclear Medicine and imaging ,General Medicine - Abstract
To evaluate if preoperative MRI can predict the most frequent HCC subtypes in North American and European patients treated with surgical resection.A total of 119 HCCs in 97 patients were included in the North American group and 191 HCCs in 176 patients were included in the European group. Lesion subtyping was based on morphologic features and immuno-histopathological analysis. Two radiologists reviewed preoperative MRI and evaluated the presence of imaging features including LI-RADS major and ancillary features to identify clinical, biologic, and imaging features associated with the main HCC subtypes.Sixty-four percent of HCCs were conventional. The most frequent subtypes were macrotrabecular-massive (MTM-15%) and steatohepatitic (13%). Necrosis (OR = 3.32; 95% CI: 1.39, 7.89; p = .0064) and observation size (OR = 1.011; 95% CI: 1.0022, 1.019; p = .014) were independent predictors of MTM-HCC. Fat in mass (OR = 15.07; 95% CI: 6.57, 34.57; p.0001), tumor size (OR = 0.97; 95% CI: 0.96, 0.99; p = .0037), and absence of chronic HCV infection (OR = 0.24; 95% CI: 0.084, 0.67; p = .0068) were independent predictors of steatohepatitic HCC. Independent predictors of conventional HCCs were viral C hepatitis (OR = 3.20; 95% CI: 1.62, 6.34; p = .0008), absence of fat (OR = 0.25; 95% CI: 0.12, 0.52; p = .0002), absence of tumor in vein (OR = 0.34; 95% CI: 0.13, 0.84; p = .020), and higher tumor-to-liver ADC ratio (OR = 1.96; 95% CI: 1.14, 3.35; p = .014) CONCLUSION: MRI is useful in predicting the most frequent HCC subtypes even in cohorts with different distributions of liver disease etiologies and tumor subtypes which might have future treatment and management implications.• Representation of both liver disease etiologies and HCC subtypes differed between the North American and European cohorts of patients. • Retrospective two-center study showed that liver MRI is useful in predicting the most frequent HCC subtypes.
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- 2022
3. Optimization of whole-body 2-[18F]FDG-PET/MRI imaging protocol for the initial staging of patients with myeloma
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Emmanuel Itti, Mojdeh Tofighi, Corinne Haioun, Sébastien Mulé, Paul Blanc-Durand, Laurence Baranes, Karim Belhadj, P. Zerbib, Robert Burns, Fabien Le Bras, and Alain Luciani
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medicine.medical_specialty ,medicine.diagnostic_test ,Mri imaging ,business.industry ,Ultrasound ,Interventional radiology ,General Medicine ,medicine.disease ,Exact test ,Positron emission tomography ,Statistical significance ,medicine ,Radiology, Nuclear Medicine and imaging ,Radiology ,business ,Multiple myeloma ,Neuroradiology - Abstract
OBJECTIVE To determine the optimal 2-[18F]FDG-PET/MRI imaging protocol for the initial staging of patients with suspected or confirmed multiple myeloma. METHODS Radiologists and nuclear medicine specialists reviewed all PET/MRI exams of 104 patients with a monoclonal gammopathy (MG). The presence of focal and diffuse bone marrow involvement (BMI) was assessed using 4 different image datasets: WB-MRI, PET, WB-PET/MRI, and WB-DCE-PET/MRI. A reference standard was established by a panel review of all baseline and follow-up imaging, and biological and pathological information. The diagnostic performance for each image dataset to detect BMI was evaluated and compared (Fisher's exact test). RESULTS Sensitivity, specificity, and accuracy for focal BMI of WB-MRI was 87%, 97%, and 92%; of PET was 78%, 97%, and 95%; of WB-PET/MRI was 93%, 97%, and 95%; and of WB-DCE-PET/MRI was 93%, 97%, and 95%, respectively. WB-PET/MRI and WB-DCE-PET/MRI were statistically superior to PET (p = 0.036) without decreasing specificity. The sensitivity, specificity, and accuracy of WB-MRI for diffuse BMI detection was 91%, 80%, and 85%; of 3DT1-PET was 53%, 89%, and 74%; of WB-PET/MRI was 98%, 66%, and 79%; and of WB-DCE-PET/MRI was 98%, 59%, and 75%, respectively. PET lacked sensitivity compared to all other dataset studies (p
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- 2021
4. Hepatospecific MR contrast agent uptake on hepatobiliary phase can be used as a biomarker of marked β-catenin activation in hepatocellular adenoma
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Julien Calderaro, Paulette Bioulac-Sage, H Trillaud, M Ghosn, Nora Frulio, Maxime Ronot, Valérie Paradis, Alain Luciani, Edouard Reizine, and Valérie Vilgrain
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medicine.medical_specialty ,medicine.diagnostic_test ,business.industry ,Mr contrast agent ,Magnetic resonance imaging ,General Medicine ,Hepatocellular adenoma ,medicine.disease ,Gastroenterology ,Hyperintensity ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,0302 clinical medicine ,Liver steatosis ,030220 oncology & carcinogenesis ,Internal medicine ,Catenin ,medicine ,Hepatobiliary phase ,Biomarker (medicine) ,Radiology, Nuclear Medicine and imaging ,Radiology ,business - Abstract
To assess the value of hepatospecific MR contrast agent uptake on hepatobiliary phase (HBP) images to detect marked activation of the β-catenin pathway in hepatocellular adenomas (HCAs). This multicentric retrospective IRB-approved study included all patients with a pathologically proven HCA who underwent gadobenate dimeglumine–enhanced liver MRI with HBP. Tumor signal intensity on HBP was first assessed visually, and lesions were classified into three distinct groups—hypointense, isointense, or hyperintense—according to the relative signal intensity to liver. Uptake was then quantified using the lesion-to-liver contrast enhancement ratio (LLCER). Finally, the accuracy of HBP analysis in depicting marked β-catenin activation in HCA was evaluated. A total of 124 HCAs were analyzed including 12 with marked β-catenin activation (HCA B+). Visual analysis classified 94/124 (76%), 12/124 (10%), and 18/124 (14%) HCAs as being hypointense, isointense, and hyperintense on HBP, respectively. Of these, 1/94 (1%), 3/12 (25%), and 8/18 (44%) were HCA B+, respectively (p
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- 2020
5. Prognostic value of anthropometric measures extracted from whole-body CT using deep learning in patients with non-small-cell lung cancer
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Simon Jégou, Frederic Pigneur, Emmanuel Itti, Paul Blanc-Durand, Luca Campedel, Sébastien Mulé, and Alain Luciani
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Oncology ,Body surface area ,medicine.medical_specialty ,Univariate analysis ,Multivariate analysis ,business.industry ,medicine.medical_treatment ,General Medicine ,Anthropometry ,medicine.disease ,030218 nuclear medicine & medical imaging ,Radiation therapy ,03 medical and health sciences ,0302 clinical medicine ,030220 oncology & carcinogenesis ,Internal medicine ,medicine ,Radiology, Nuclear Medicine and imaging ,In patient ,Non small cell ,Radiology ,Lung cancer ,business - Abstract
The aim of the study was to extract anthropometric measures from CT by deep learning and to evaluate their prognostic value in patients with non-small-cell lung cancer (NSCLC). A convolutional neural network was trained to perform automatic segmentation of subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and muscular body mass (MBM) from low-dose CT images in 189 patients with NSCLC who underwent pretherapy PET/CT. After a fivefold cross-validation in a subset of 35 patients, anthropometric measures extracted by deep learning were normalized to the body surface area (BSA) to control the various patient morphologies. VAT/SAT ratio and clinical parameters were included in a Cox proportional-hazards model for progression-free survival (PFS) and overall survival (OS). Inference time for a whole volume was about 3 s. Mean Dice similarity coefficients in the validation set were 0.95, 0.93, and 0.91 for SAT, VAT, and MBM, respectively. For PFS prediction, T-stage, N-stage, chemotherapy, radiation therapy, and VAT/SAT ratio were associated with disease progression on univariate analysis. On multivariate analysis, only N-stage (HR = 1.7 [1.2–2.4]; p = 0.006), radiation therapy (HR = 2.4 [1.0–5.4]; p = 0.04), and VAT/SAT ratio (HR = 10.0 [2.7–37.9]; p
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- 2020
6. Breast arterial calcifications on mammography: a new marker of cardiovascular risk in asymptomatic middle age women?
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Lise Minssen, Thu Ha Dao, An Vo Quang, Laura Martin, Etienne Andureau, Alain Luciani, Evelyne Meyblum, Geneviève Derumeaux, and Jean-François Deux
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Adult ,General Medicine ,Coronary Artery Disease ,Middle Aged ,Breast Diseases ,Cardiovascular Diseases ,Heart Disease Risk Factors ,Risk Factors ,Humans ,Radiology, Nuclear Medicine and imaging ,Female ,Breast ,Vascular Calcification ,Aged ,Mammography ,Retrospective Studies - Abstract
To determine whether breast arterial calcification (BAC) detected on mammography can predict the presence of coronary artery calcification (CAC) on CT in women.Women explored with both mammography and thoracic CT from 2009 to 2018 were retrospectively included. Women were separated in 3 categories (no BAC, few BAC, and marked BAC) using a specific 12-point scale. Similar scale was used to evaluate the amount of CAC on CT. The mean sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy of BAC for the detection of CAC were calculated. Statistical significance was assessed with Pearson's chi-squared test and Fisher's exact test as appropriate.A total of 507 women (mean age: 62 years ± 16) were included. Patients with high amount of BAC were older (72 ± 11 vs. 59 ± 15 years old; p.0001), were more frequently hypertensive (66% vs. 31%; p.0001), and had more frequently renal failure (21% vs. 6%; p.0003) than patients without BAC. The sensitivity, specificity, PPV, NPV, and diagnostic accuracy of BAC for the detection of women with marked CAC were 53.1%, 87.6%, 55.0%, 86.7%, and 79.9%, respectively. The highest diagnostic accuracy was obtained in patients under 60 years: 84.2% for detection of CAC and 93.2% for detection of women with marked CAC.The presence of BAC on mammography was linked to the presence of CAC and may be used as a cardiovascular marker in patient less than 60 years.• The diagnostic accuracy of breast arterial calcification (BAC) to detect the presence of coronary artery calcification (CAC) was 70.4% and reached to 79.9% to detect women with high amount of CAC. • Highest diagnostic accuracy of BAC to detect CAC (93.2%) was noticed in women under 60 years. • The presence of BAC on mammography may be used as a cardiovascular risk marker in women, especially under 60 years.
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- 2021
7. Optimization of whole-body 2-[
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Robert, Burns, Sébastien, Mulé, Paul, Blanc-Durand, Mojdeh, Tofighi, Karim, Belhadj, Pierre, Zerbib, Fabien, Le Bras, Laurence, Baranes, Corinne, Haioun, Emmanuel, Itti, and Alain, Luciani
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Diffusion Magnetic Resonance Imaging ,Fluorodeoxyglucose F18 ,Positron Emission Tomography Computed Tomography ,Positron-Emission Tomography ,Humans ,Whole Body Imaging ,Radiopharmaceuticals ,Multiple Myeloma ,Magnetic Resonance Imaging ,Neoplasm Staging - Abstract
To determine the optimal 2-[Radiologists and nuclear medicine specialists reviewed all PET/MRI exams of 104 patients with a monoclonal gammopathy (MG). The presence of focal and diffuse bone marrow involvement (BMI) was assessed using 4 different image datasets: WB-MRI, PET, WB-PET/MRI, and WB-DCE-PET/MRI. A reference standard was established by a panel review of all baseline and follow-up imaging, and biological and pathological information. The diagnostic performance for each image dataset to detect BMI was evaluated and compared (Fisher's exact test).Sensitivity, specificity, and accuracy for focal BMI of WB-MRI was 87%, 97%, and 92%; of PET was 78%, 97%, and 95%; of WB-PET/MRI was 93%, 97%, and 95%; and of WB-DCE-PET/MRI was 93%, 97%, and 95%, respectively. WB-PET/MRI and WB-DCE-PET/MRI were statistically superior to PET (p = 0.036) without decreasing specificity. The sensitivity, specificity, and accuracy of WB-MRI for diffuse BMI detection was 91%, 80%, and 85%; of 3DT1-PET was 53%, 89%, and 74%; of WB-PET/MRI was 98%, 66%, and 79%; and of WB-DCE-PET/MRI was 98%, 59%, and 75%, respectively. PET lacked sensitivity compared to all other dataset studies (p 0.0001). WB-MRI had the best accuracy without reaching statistical significance when compared to the other datasets.The WB-PET/MRI dataset including T1 and T2 Dixon, WB-DWI, and PET images provides optimal diagnostic performance to detect both focal lesions and diffuse BMI, with limited added value of WB-DCE for baseline staging of patients with MG. Key Points • The combination of morphological and functional MRI sequences and metabolic (2-[
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- 2021
8. Autofluorescence imaging within the liver: a promising tool for the detection and characterization of primary liver tumors
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Nicolas Poté, René Farcy, Hervé Puy, Fouad Lafdil, Charlotte Benoit, Jean-Charles Deybach, J. Calderaro, E. Itti, Laurent Gouya, Caroline Schmitt, Aurélie Rodrigues, Valérie Vilgrain, Sébastien Mulé, Valérie Paradis, Cécile Charpy, Alain Luciani, and Sylvie Simonin
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Pathology ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Sensitivity and Specificity ,Parenchyma ,Biopsy ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,Intrahepatic Cholangiocarcinomas ,Neuroradiology ,medicine.diagnostic_test ,business.industry ,Ultrasound ,Liver Neoplasms ,Optical Imaging ,General Medicine ,Autofluorescence ,Bile Ducts, Intrahepatic ,Bile Duct Neoplasms ,Liver ,Liver biopsy ,Radiology ,business ,Ex vivo - Abstract
To assess the performance of 405 nm-induced autofluorescence for the characterization of primary liver nodules on ex vivo resected specimens.Forty resected liver specimens bearing 53 primary liver nodules were included in this IRB-approved prospective study. Intratissular spectroscopic measurements were performed using a 25-G fibered-needle on all ex vivo specimens: 5 autofluorescence measurements were performed in both nodules and adjacent parenchyma. The spectra derivatives of the 635 and 670 nm autofluorescence peaks observed in nodules and in adjacent liver parenchyma were compared (Kruskal-Wallis and Mann-Whitney when appropriate).A total of 42 potentially evolutive primary liver nodules-34 hepatocellular carcinomas, 4 intrahepatic cholangiocarcinomas, 4 hepatocellular adenomas-and 11 benign nodules-5 focal nodular hyperplasias, 6 regenerative nodules-were included. Both 635 and 670 nm Δderivatives were significantly higher in benign as compared to potentially evolutive (PEV) nodules (respectively 32.9 ± 4.5 vs 15.3 ± 1.4; p 0.0001 and 5.7 ± 0.6 vs 2.5 ± 0.1; p 0.0001) with respective sensitivity and specificity of 78% and 91% for distinguishing PEV from benign nodules.405 nm-induced autofluorescence enables the discrimination of benign from PEV primary liver nodules, suggesting that autofluorescence imaging could be used to optimize US targeted liver biopsies.• 405 nm-induced autofluorescence can distinguish liver tumors from the adjacent liver parenchyma. • The analysis of autofluorescence imaging observed within primary liver tumors can discriminate benign tumors from those requiring follow-up or targeted liver biopsy. • In current practice, autofluorescence imaging could be embedded within biopsy needle, to enable, in addition to ultrasound guidance, optimal targeting of liver nodules which could optimize tissue sampling.
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- 2021
9. Hepatobiliary MR contrast agent uptake as a predictive biomarker of aggressive features on pathology and reduced recurrence-free survival in resectable hepatocellular carcinoma: comparison with dual-tracer 18F-FDG and 18F-FCH PET/CT
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Julia Chalaye, Alain Luciani, Arthur Tenenhaus, Rym Kharrat, Alexis Laurent, Vania Tacher, Julien Calderaro, Giuliana Amaddeo, F. Legou, Hicham Kobeiter, Emmanuel Itti, Hélène Regnault, Sébastien Mulé, Athena Galletto Pregliasco, Service de radiothérapie [Reims], Institut du cancer Courlancy-Reims, CHU Henri Mondor, Laboratoire des signaux et systèmes (L2S), CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Université Paris-Est Créteil Val-de-Marne - Faculté de médecine (UPEC Médecine), Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Ospedali Galliera, Danmarks Tekniske Universitet = Technical University of Denmark (DTU), Service d'hépato-gastro-entérologie [APHP Henri Mondor], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), and Technical University of Denmark [Lyngby] (DTU)
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Adult ,Male ,Pathology ,medicine.medical_specialty ,Fluorine Radioisotopes ,Carcinoma, Hepatocellular ,Contrast Media ,Disease-Free Survival ,030218 nuclear medicine & medical imaging ,Choline ,03 medical and health sciences ,0302 clinical medicine ,Meglumine ,Resectable Hepatocellular Carcinoma ,[STAT.ML]Statistics [stat]/Machine Learning [stat.ML] ,[MATH.MATH-ST]Mathematics [math]/Statistics [math.ST] ,Fluorodeoxyglucose F18 ,Recurrence ,Positron Emission Tomography Computed Tomography ,medicine ,Organometallic Compounds ,Humans ,Radiology, Nuclear Medicine and imaging ,ComputingMilieux_MISCELLANEOUS ,Neuroradiology ,Aged ,Neoplasm Staging ,Retrospective Studies ,Aged, 80 and over ,PET-CT ,[STAT.AP]Statistics [stat]/Applications [stat.AP] ,medicine.diagnostic_test ,Receiver operating characteristic ,Proportional hazards model ,business.industry ,Liver Neoplasms ,Magnetic resonance imaging ,Interventional radiology ,General Medicine ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,Female ,Radiology ,Radiopharmaceuticals ,business ,[STAT.ME]Statistics [stat]/Methodology [stat.ME] - Abstract
To compare the performance of the quantitative analysis of the hepatobiliary phase (HBP) tumor enhancement in gadobenate dimeglumine (Gd-BOPTA)–enhanced MRI and of dual-tracer 18F-FDG and 18F-fluorocholine (FCH) PET/CT for the prediction of tumor aggressiveness and recurrence-free survival (RFS) in resectable hepatocellular carcinoma (HCC). This retrospective, IRB approved study included 32 patients with 35 surgically proven HCCs. All patients underwent Gd-BOPTA-enhanced MRI including delayed HBP images, 18F-FDG PET/CT, and (for 29/32 patients) 18F-FCH PET/CT during the 2 months prior to surgery. For each lesion, the lesion-to-liver contrast enhancement ratio (LLCER) on MRI HBP images and the SUVmax tumor-to-liver ratio (SUVT/L) for both tracers were calculated. Their predictive value for aggressive pathological features—including the histological grade and microvascular invasion (MVI)—and RFS were analyzed and compared using area under receiver operating characteristic (AUROC) curves and Cox regression models, respectively. The AUROCs for the identification of aggressive HCCs on pathology with LLCER, 18F-FDG SUVT/L, and 18F-FCH SUVT/L were 0.92 (95% CI 0.78, 0.98), 0.89 (95% CI 0.74, 0.97; p = 0.70), and 0.64 (95% CI 0.45, 0.80; p = 0.035). At multivariate Cox regression analysis, LLCER was identified as an independent predictor of RFS (HR (95% CI) = 0.91 (0.84, 0.99), p = 0.022). LLCER − 4.72% or less also accurately predicted moderate-poor differentiation grade (Se = 100%, Sp = 92.9%) and MVI (Se = 93.3%, Sp = 60%) and identified patients with poor RFS after surgical resection (p = 0.030). HBP tumor enhancement after Gd-BOPTA injection may help identify aggressive HCC pathological features, and patients with reduced recurrence-free survival after surgical resection. • In patients with resectable HCC, the quantitative analysis of the HBP tumor enhancement in Gd-BOPTA-enhanced MRI (LLCER) accurately identifies moderately-poorly differentiated and/or MVI-positive HCCs. • After surgical resection for HCC, patients with LLCER − 4.72% or less had significantly poorer recurrence-free survival than patients with LLCER superior to − 4.72%. • Gd-BOPTA-enhanced MRI with delayed HBP images may be suggested as part of pre-surgery workup in patients with resectable HCC.
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- 2020
10. Quantitative correlation between uptake of Gd-BOPTA on hepatobiliary phase and tumor molecular features in patients with benign hepatocellular lesions
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Laurence Baranes, B. Zegai, Julien Calderaro, Giuliana Amaddeo, Vincent Roche, F. Legou, Alexis Laurent, Edouard Reizine, Frederic Pigneur, Sébastien Mulé, Alain Luciani, and Alain Rahmouni
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Adult ,Gadolinium DTPA ,Male ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Adenoma ,Imaging biomarker ,Organic anion transporter 1 ,Contrast Media ,Organic Anion Transporters ,Sensitivity and Specificity ,Gastroenterology ,Adenoma, Liver Cell ,030218 nuclear medicine & medical imaging ,Diagnosis, Differential ,03 medical and health sciences ,Meglumine ,0302 clinical medicine ,Internal medicine ,Organometallic Compounds ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Aged ,Retrospective Studies ,biology ,business.industry ,Liver Neoplasms ,Focal nodular hyperplasia ,General Medicine ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,HNF1A ,Focal Nodular Hyperplasia ,Hepatobiliary phase ,biology.protein ,Immunohistochemistry ,Female ,030211 gastroenterology & hepatology ,Radiology ,business ,Quantitative analysis (chemistry) - Abstract
The purpose of our study was to correlate the quantitative analysis of benign hepatocellular tumor uptake on delayed hepatobiliary phase (HBP) imaging with the quantitative level of OATP expression. This single-center retrospective study, which took place between September 2009 and March 2015, included 20 consecutive patients with a proven pathologic and immunohistochemical (IHC) diagnosis of FNH or HCA, including quantification of the OATP expression. The patients underwent Gd-BOPTA-enhancement MRI, including an HBP. The analysis of HBP uptake was performed using the liver-to-lesion contrast enhancement ratio (LLCER). Mean LLCER and OATP expressions were compared between FNH and HCA, and the expression of OATP was correlated with the LLCER value. Of the 23 benign hepatocellular tumors, 9 (39%) were FNH and 14 (61%) were HCA, including 6 inflammatory, 2 HNF1a inactivated, 3 β-catenin-mutated and 3 unclassified HCAs. On HBP, 100% of the FNH appeared hyper- or isointense, and 79% of the adenomas appeared hypointense. The mean OATP expression of FNH (46.67 ± 26.58%) was significantly higher than that of HCA (22.14 ± 30.74%) (p = 0.0273), and the mean LLCER of FNH (10.66 ± 7.403%) was significantly higher than that of HCA (-13.5 ± 12.25%) (p < 0.0001). The mean LLCER of β-catenin-mutated HCA was significantly higher than that of other HCAs (p = 0.011). Significant correlation was found between the OATP expression and LLCER values (r = 0.661; p = 0.001). In benign hepatocellular tumors, the quantitative analysis of hepatobiliary contrast agent uptake on HBP is correlated with the level of OATP expression and could be used as an imaging biomarker of the molecular background of HCA and FNH. • Gd-BOPTA uptake on HBP correlates with the OATP level in benign hepatocellular tumors • FNH and β-catenin-mutated HCA showed an increased lesion-to-liver contrast enhancement ratio (LLCER) • Increased LLCER may be explained by activation of the Wnt β-catenin pathway
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- 2018
11. Myocardial iodine concentration measurement using dual-energy computed tomography for the diagnosis of cardiac amyloidosis: a pilot study
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F. Legou, Hicham Kobeiter, Virgile Chevance, Fourat Ridouani, Jean-François Deux, Alain Luciani, Alain Rahmouni, Vania Tacher, and Thibaud Damy
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Male ,medicine.medical_specialty ,Blood pool ,Iomeprol ,chemistry.chemical_element ,Pilot Projects ,030204 cardiovascular system & hematology ,Iodine ,030218 nuclear medicine & medical imaging ,03 medical and health sciences ,chemistry.chemical_compound ,0302 clinical medicine ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Aged ,business.industry ,Myocardium ,Ultrasound ,Area under the curve ,Dual-Energy Computed Tomography ,Amyloidosis ,General Medicine ,Blood flow ,Cardiomyopathy, Hypertrophic ,Cardiac amyloidosis ,chemistry ,Radiographic Image Interpretation, Computer-Assisted ,Female ,Radiology ,Cardiomyopathies ,Tomography, X-Ray Computed ,business - Abstract
To measure myocardium iodine concentration (MIC) in patients with cardiac amyloidosis (CA) using dual-energy computed tomography (DECT). Twenty-two patients with CA, 13 with non-amyloid hypertrophic cardiomyopathies (CH) and 10 control patients were explored with pre-contrast, arterial and 5-minute DECT acquisition (Iomeprol; 1.5 mL/kg). Inter-ventricular septum (IVS) thickness, blood pool iodine concentration (BPIC), MIC (mg/mL), iodine ratio and extra-cellular volume (ECV) were calculated. IVS thickness was significantly (p
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- 2017
12. Prognostic value of anthropometric measures extracted from whole-body CT using deep learning in patients with non-small-cell lung cancer
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Paul, Blanc-Durand, Luca, Campedel, Sébastien, Mule, Simon, Jegou, Alain, Luciani, Frédéric, Pigneur, and Emmanuel, Itti
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Adult ,Male ,Lung Neoplasms ,Body Surface Area ,Subcutaneous Fat ,Reproducibility of Results ,Intra-Abdominal Fat ,Middle Aged ,Prognosis ,Progression-Free Survival ,Survival Rate ,Deep Learning ,Carcinoma, Non-Small-Cell Lung ,Positron Emission Tomography Computed Tomography ,Body Composition ,Disease Progression ,Humans ,Female ,Whole Body Imaging ,Muscle, Skeletal ,Aged ,Neoplasm Staging ,Proportional Hazards Models - Abstract
The aim of the study was to extract anthropometric measures from CT by deep learning and to evaluate their prognostic value in patients with non-small-cell lung cancer (NSCLC).A convolutional neural network was trained to perform automatic segmentation of subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT), and muscular body mass (MBM) from low-dose CT images in 189 patients with NSCLC who underwent pretherapy PET/CT. After a fivefold cross-validation in a subset of 35 patients, anthropometric measures extracted by deep learning were normalized to the body surface area (BSA) to control the various patient morphologies. VAT/SAT ratio and clinical parameters were included in a Cox proportional-hazards model for progression-free survival (PFS) and overall survival (OS).Inference time for a whole volume was about 3 s. Mean Dice similarity coefficients in the validation set were 0.95, 0.93, and 0.91 for SAT, VAT, and MBM, respectively. For PFS prediction, T-stage, N-stage, chemotherapy, radiation therapy, and VAT/SAT ratio were associated with disease progression on univariate analysis. On multivariate analysis, only N-stage (HR = 1.7 [1.2-2.4]; p = 0.006), radiation therapy (HR = 2.4 [1.0-5.4]; p = 0.04), and VAT/SAT ratio (HR = 10.0 [2.7-37.9]; p 0.001) remained significant prognosticators. For OS, male gender, smoking status, N-stage, a lower SAT/BSA ratio, and a higher VAT/SAT ratio were associated with mortality on univariate analysis. On multivariate analysis, male gender (HR = 2.8 [1.2-6.7]; p = 0.02), N-stage (HR = 2.1 [1.5-2.9]; p 0.001), and the VAT/SAT ratio (HR = 7.9 [1.7-37.1]; p 0.001) remained significant prognosticators.The BSA-normalized VAT/SAT ratio is an independent predictor of both PFS and OS in NSCLC patients.• Deep learning will make CT-derived anthropometric measures clinically usable as they are currently too time-consuming to calculate in routine practice. • Whole-body CT-derived anthropometrics in non-small-cell lung cancer are associated with progression-free survival and overall survival. • A priori medical knowledge can be implemented in the neural network loss function calculation.
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- 2019
13. Iso- or hyperintensity of hepatocellular adenomas on hepatobiliary phase does not always correspond to hepatospecific contrast-agent uptake: importance for tumor subtyping
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Maxime Ronot, Edouard Reizine, Julien Calderaro, Marco Dioguardi Burgio, Alexis Laurent, Valérie Vilgrain, Yvonne Purcell, Frederic Pigneur, Sébastien Mulé, Giuliana Amaddeo, and Alain Luciani
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Adult ,Gadolinium DTPA ,Male ,medicine.medical_specialty ,Adenoma ,media_common.quotation_subject ,Biopsy ,Contrast Media ,Gastroenterology ,030218 nuclear medicine & medical imaging ,Adenoma, Liver Cell ,03 medical and health sciences ,Young Adult ,0302 clinical medicine ,Precontrast ,Internal medicine ,medicine ,Contrast (vision) ,Humans ,Radiology, Nuclear Medicine and imaging ,media_common ,Neuroradiology ,Neoplasm Staging ,Retrospective Studies ,medicine.diagnostic_test ,business.industry ,Liver Neoplasms ,Magnetic resonance imaging ,General Medicine ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Hyperintensity ,Liver ,030220 oncology & carcinogenesis ,Hepatobiliary phase ,Female ,Radiology ,Steatosis ,business - Abstract
This study was conducted in order to evaluate if iso- or hyperintensity of HCAs on HBP is systematically related to a high uptake of hepatospecific contrast agent, using a quantitative approach. This bicentric retrospective study included all patients with histologically confirmed and subtyped HCA from 2009 to 2017 who underwent MRI with HBP after Gd-BOPTA injection and who showed iso- or hyperintensity on HBP. The signal intensity of tumors on pre- and postcontrast images and the presence of hepatic steatosis were noted. Contrast uptake on HBP was quantified using the liver-to-lesion contrast enhancement ratio (LLCER) and compared between HCA subtypes (Wilcoxon signed-rank test). Categorical variables were compared using chi-square tests. Twenty-four HCAs showed iso- or hyperintensity on HBP, specifically 17 inflammatory (IHCAs) and 7 β-catenin HCAs (BHCAs). Eighteen HCAs (75%) (17 IHCAs and 1 BHCAs) had a LLCER
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- 2018
14. Use of Model-Based Iterative Reconstruction (MBIR) in reduced-dose CT for routine follow-up of patients with malignant lymphoma: dose savings, image quality and phantom study
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Alain Rahmouni, M. Chiaradia, Philippe Richard, Emmanuel Itti, Edouard Herin, Jean-François Deux, Alain Luciani, Pauline Beaussart, François Gardavaud, Madeleine Cavet, and Corinne Haioun
- Subjects
Adult ,Male ,medicine.medical_specialty ,Lymphoma ,Image quality ,Image processing ,Iterative reconstruction ,Signal-To-Noise Ratio ,Radiation Dosage ,Imaging phantom ,Malignant lymphoma ,Young Adult ,Image Processing, Computer-Assisted ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Aged ,Neuroradiology ,Aged, 80 and over ,Phantoms, Imaging ,business.industry ,Ultrasound ,General Medicine ,Middle Aged ,Radiographic Image Interpretation, Computer-Assisted ,Female ,Radiology ,Tomography ,Tomography, X-Ray Computed ,business ,Nuclear medicine ,Algorithms ,Follow-Up Studies - Abstract
To evaluate both in vivo and in phantom studies, dose reduction, and image quality of body CT reconstructed with model-based iterative reconstruction (MBIR), performed during patient follow-ups for lymphoma.This study included 40 patients (mean age 49 years) with lymphoma. All underwent reduced-dose CT during follow-up, reconstructed using MBIR or 50 % advanced statistical iterative reconstruction (ASIR). All had previously undergone a standard dose CT with filtered back projection (FBP) reconstruction. The volume CT dose index (CTDIvol), the density measures in liver, spleen, fat, air, and muscle, and the image quality (noise and signal to noise ratio, SNR) (ANOVA) observed using standard or reduced-dose CT were compared both in patients and a phantom study (Catphan 600) (Kruskal Wallis).The CTDIvol was decreased on reduced-dose body CT (4.06 mGy vs. 15.64 mGy p 0.0001). SNR was higher in reduced-dose CT reconstructed with MBIR than in 50 % ASIR or than standard dose CT with FBP (patients, p ≤ 0.01; phantoms, p = 0.003). Low contrast detectability and spatial resolution in phantoms were not altered on MBIR-reconstructed CT (p ≥ 0.11).Reduced-dose CT with MBIR reconstruction can decrease radiation dose delivered to patients with lymphoma, while keeping an image quality similar to that obtained on standard-dose CT.• In lymphoma patients, CT dose reduction is a major concern. • Reduced-dose body CT provides a fourfold radiation dose reduction. • Optimized CT reconstruction techniques (MBIR) can maintain image quality.
- Published
- 2015
15. Noninvasive detection of cardiac amyloidosis using delayed enhanced MDCT: a pilot study
- Author
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Alain Rahmouni, Thibaud Damy, Julie Mayer, Violaine Planté-Bordeneuve, Jean-François Deux, Alain Luciani, F. Legou, Hicham Kobeiter, Cristian-Ionut Mihalache, and Stéphane Rappeneau
- Subjects
Male ,medicine.medical_specialty ,Heart Diseases ,Blood pool ,Contrast Media ,Pilot Projects ,Computed tomography ,Signal-To-Noise Ratio ,Muscle hypertrophy ,Internal medicine ,Multidetector Computed Tomography ,Image Processing, Computer-Assisted ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Aged ,Neuroradiology ,medicine.diagnostic_test ,business.industry ,Amyloidosis ,Ultrasound ,Reproducibility of Results ,Heart ,Interventional radiology ,General Medicine ,Middle Aged ,medicine.disease ,Radiographic Image Enhancement ,Cardiac amyloidosis ,Cardiology ,Female ,Radiology ,business - Abstract
To evaluate myocardial enhancement of patients with cardiac amyloidosis (CA) using computed tomography (CT). Thirteen patients with CA and 11 control patients were examined with first-pass and delayed CT acquisition. A qualitative and quantitative analysis of images was performed. Myocardial attenuation, myocardial signal-to-noise ratio (SNRmyoc), blood pool SNR (SNRblood), contrast-to-noise ratio between blood pool and myocardium (CNRblood-myoc) and relative attenuation index (RAI) defined as variation of myocardial attenuation between delayed and first-pass acquisitions were calculated. Two false negative cases (15 %) and three false positive cases (27 %) were detected on qualitative analysis. SNRmyoc of patients with CA was significantly (p
- Published
- 2015
16. Can dual-energy CT replace perfusion CT for the functional evaluation of advanced hepatocellular carcinoma?
- Author
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H. Pasquier, Sébastien Mulé, Laurence Baranes, Ronan Quelever, Maxime Ronot, Frederic Pigneur, Alain Rahmouni, Edouard Herin, Alain Luciani, Philippe Richard, Valérie Vilgrain, Vania Tacher, Arthur Tenenhaus, Service de radiothérapie [Reims], Institut du cancer Courlancy-Reims, Service de Radiologie [Mondor], Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12)-Hôpital Henri Mondor-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Laboratoire des signaux et systèmes (L2S), CentraleSupélec-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS), Service d'imagerie médicale, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Journaliste, AFP, Institut Mondor de Recherche Biomédicale (IMRB), Institut National de la Santé et de la Recherche Médicale (INSERM)-IFR10-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Hôpital Beaujon, Hôpital Beaujon [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)
- Subjects
Sorafenib ,Male ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Perfusion Imaging ,chemistry.chemical_element ,Contrast Media ,Perfusion scanning ,Blood volume ,Iodine ,030218 nuclear medicine & medical imaging ,Radiography, Dual-Energy Scanned Projection ,03 medical and health sciences ,0302 clinical medicine ,[STAT.ML]Statistics [stat]/Machine Learning [stat.ML] ,[MATH.MATH-ST]Mathematics [math]/Statistics [math.ST] ,Medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Prospective Studies ,ComputingMilieux_MISCELLANEOUS ,Aged ,Aged, 80 and over ,[STAT.AP]Statistics [stat]/Applications [stat.AP] ,business.industry ,Ultrasound ,Liver Neoplasms ,Reproducibility of Results ,General Medicine ,Blood flow ,Middle Aged ,medicine.disease ,Iopamidol ,Radiographic Image Enhancement ,chemistry ,Liver ,030220 oncology & carcinogenesis ,Hepatocellular carcinoma ,Female ,Radiology ,business ,Tomography, X-Ray Computed ,Perfusion ,[STAT.ME]Statistics [stat]/Methodology [stat.ME] ,medicine.drug - Abstract
To determine the degree of relationship between iodine concentrations derived from dual-energy CT (DECT) and perfusion CT parameters in patients with advanced HCC under treatment. In this single-centre IRB approved study, 16 patients with advanced HCC treated with sorafenib or radioembolization who underwent concurrent dynamic perfusion CT and multiphase DECT using a single source, fast kV switching DECT scanner were included. Written informed consent was obtained for all patients. HCC late-arterial and portal iodine concentrations, blood flow (BF)-related and blood volume (BV)-related perfusion parameters maps were calculated. Mixed-effects models of the relationship between iodine concentrations and perfusion parameters were computed. An adjusted p value (Bonferroni method) < 0.05 was considered significant. Mean HCC late-arterial and portal iodine concentrations were 22.7±12.7 mg/mL and 18.7±8.3 mg/mL, respectively. Late-arterial iodine concentration was significantly related to BV (mixed-effects model F statistic (F)=28.52, p
- Published
- 2017
17. Differentiation of focal nodular hyperplasia from hepatocellular adenomas with low-mecanical-index contrast-enhanced sonography (CEUS): effect of size on diagnostic confidence
- Author
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Laurence Baranes, Frederic Pigneur, Vincent Roche, Alain Luciani, Charlotte Costentin, Lambros Tselikas, Marion Roux, Alexis Laurent, M. Djabbari, Julien Calderaro, and Alain Rahmouni
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adenoma ,Contrast Media ,Adenoma, Liver Cell ,Diagnosis, Differential ,Lesion ,Young Adult ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Ultrasonography, Doppler, Color ,Aged ,Retrospective Studies ,Neuroradiology ,business.industry ,Liver Neoplasms ,Ultrasound ,Focal nodular hyperplasia ,General Medicine ,Middle Aged ,Hepatocellular adenoma ,medicine.disease ,ROC Curve ,Focal Nodular Hyperplasia ,Female ,Radiology ,Differential diagnosis ,medicine.symptom ,business ,Mechanical index - Abstract
The purpose of this study was to assess the diagnostic performance of contrast-enhanced sonography (CEUS) for the differentiation of focal nodular hyperplasia (FNH) from hepatocellular adenoma (HCA) according to lesion size. Forty patients with a definite diagnosis of FNH or HCA who underwent CEUS were included in this institutional review board (IRB)-approved study. A total of 43 FNHs and 20 HCAs, including 15 inflammatory HCAs and five unclassified HCAs, were analysed. Two radiologists reviewed the diagnostic CEUS parameters separately and in consensus, including the presence or absence of centrifugal filling and central vessels. The sensitivity (Se), specificity (Sp), and inter-observer confidence (Kappa) of CEUS diagnostic parameters were assessed. Inter-observer agreement of CEUS for FNH diagnosis was high (kappa = 0.81) with an overall Se of 67.4 % [29/43 (CI 95 %: 51.4–80.1 %)] and an Sp of 100 % [20/20 (CI 95 %: 81–100 %)]. Significantly higher Se figures were found for lesions ≤ 35 mm than for lesions > 35 mm [respectively, 93 % (28/30) (CI 95 %: 77.6–99.2) vs. 7.7 % (1/13) (CI 95 %: 0.2–36 %), p = 0.002] with unchanged specificity. CEUS is highly specific for the diagnosis of FNH, with very good inter-observer agreement, whatever the size, but its sensitivity is significantly reduced in diagnosing lesions larger than 35 mm. • CEUS is highly specific for the diagnosis of FNH, regardless of lesion size • CEUS shows reduced sensitivity in diagnosing FNH lesions larger than 35 mm • The filling patterns of hepatocellular adenomas are not affected by lesion size
- Published
- 2014
18. Whole-body diffusion-weighted magnetic resonance imaging with apparent diffusion coefficient mapping for staging patients with diffuse large B-cell lymphoma
- Author
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Corinne Haioun, Michel Meignan, Alain Luciani, Emmanuel Itti, Chieh Lin, Eva Evangelista, Pauline Beaussart, Taoufik El-Gnaoui, Alexandre Vignaud, Karim Belhadj, Pierre Brugières, S. Lin, and Alain Rahmouni
- Subjects
Adult ,medicine.medical_specialty ,Whole body imaging ,Sensitivity and Specificity ,hemic and lymphatic diseases ,Image Interpretation, Computer-Assisted ,medicine ,Humans ,Effective diffusion coefficient ,Whole Body Imaging ,Radiology, Nuclear Medicine and imaging ,Aged ,Neoplasm Staging ,Neuroradiology ,medicine.diagnostic_test ,business.industry ,Reproducibility of Results ,General Medicine ,Middle Aged ,Image Enhancement ,medicine.disease ,Lymphoma ,Diffusion Magnetic Resonance Imaging ,Lymphoma, Large B-Cell, Diffuse ,Tomography ,Radiology ,Nuclear medicine ,business ,Diffuse large B-cell lymphoma ,Emission computed tomography ,Diffusion MRI - Abstract
To design a whole-body MR protocol using exclusively diffusion-weighted imaging (DWI) with respiratory gating and to assess its value for lesion detection and staging in patients with diffuse large B-cell lymphoma (DLBCL), with integrated FDG PET/CT as the reference standard.Fifteen patients underwent both whole-body DWI (b = 50, 400, 800 s/mm(2)) and PET/CT for pretreatment staging. Lymph node and organ involvement were evaluated by qualitative and quantitative image analysis, including measurement of the mean apparent diffusion coefficient (ADC).A total of 296 lymph node regions in the 15 patients were analysed. Based on International Working Group size criteria alone, DWI findings matched PET/CT findings in 277 regions (94%) (kappa score = 0.85, P0.0001), yielding sensitivity and specificity for DWI lymph node involvement detection of 90% and 94%. Combining visual ADC analysis with size measurement increased DWI specificity to 100% with 81% sensitivity. For organ involvement, the two techniques agreed in all 20 recorded organs (100%). All involved organ lesions showed restricted diffusion. Ann Arbor stages agreed in 14 (93%) of the 15 patients.Whole-body DWI with ADC analysis can potentially be used for lesion detection and staging in patients with DLBCL.
- Published
- 2010
19. Diffusion-weighted echo planar imaging in patients with recent myocardial infarction
- Author
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Pascal Lim, Jean-Luc Dubois-Randé, Grégory Lenczner, J. Mayer, Hicham Kobeiter, Alain Luciani, Alexandre Vignaud, Alain Rahmouni, Mezri Maatouk, and Jean-François Deux
- Subjects
Male ,medicine.medical_specialty ,Radiography ,Myocardial Infarction ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,In patient ,Myocardial infarction ,Neuroradiology ,Aged ,Echo-planar imaging ,Aged, 80 and over ,medicine.diagnostic_test ,business.industry ,Echo-Planar Imaging ,Ultrasound ,Magnetic resonance imaging ,General Medicine ,Middle Aged ,medicine.disease ,Diffusion Magnetic Resonance Imaging ,Female ,Radiology ,business ,Nuclear medicine ,Recent myocardial infarction - Abstract
To evaluate a diffusion-weighted (DW) black blood MR sequence for the detection of myocardium signal abnormalities in patients with recent myocardial infarction (MI). A DW black blood EPI sequence was acquired at 1.5 T in 12 patients with recent MI. One slice per patient was acquired with b = 0 and b = 50 s/mm2. A standard short tau inversion recovery (STIR) T2-weighted sequence was acquired at the same level. Viability was assessed with delayed-enhancement sequences. Images were analyzed qualitatively and quantitatively. A non parametric Wilcoxon test was used for statistical analysis, with a significance level of P
- Published
- 2010
20. Magnetic targeting of iron-oxide-labeled fluorescent hepatoma cells to the liver
- Author
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Alain Luciani, Florence Gazeau, Patrick Bruneval, Claire Wilhelm, Gwennhael Autret, Olivier Clément, Alain Rahmouni, and Patrick Cunin
- Subjects
Male ,Pathology ,medicine.medical_specialty ,Carcinoma, Hepatocellular ,Cell Transplantation ,Confocal ,Liver cell transplantation ,Cell ,Iron oxide ,Ferric Compounds ,chemistry.chemical_compound ,Magnetics ,Mice ,Microscopy, Electron, Transmission ,Cell Line, Tumor ,Fluorescence microscope ,medicine ,Distribution (pharmacology) ,Animals ,Radiology, Nuclear Medicine and imaging ,Fluorescent Dyes ,Microscopy, Confocal ,business.industry ,Liver Neoplasms ,Histology ,General Medicine ,equipment and supplies ,Fluorescence ,Magnetic Resonance Imaging ,Mice, Inbred C57BL ,medicine.anatomical_structure ,chemistry ,Liver ,business ,human activities ,Spleen - Abstract
The purpose of this study was to determine whether an external magnet field can induce preferential trafficking of magnetically labeled Huh7 hepatoma cells to the liver following liver cell transplantation. Huh7 hepatoma cells were labeled with anionic magnetic nanoparticles (AMNP) and tagged with a fluorescent membrane marker (PKH67). Iron-uptake was measured by magnetophoresis. Twenty C57Bl6 mice received an intrasplenic injection of 2 × 106 labeled cells. An external magnet (0.29 T; 25 T/m) was placed over the liver of 13 randomly selected animals (magnet group), while the remaining 7 animals served as controls. MRI (1.5 T) and confocal fluorescence microscopy (CFM) were performed 10 days post-transplantation. The presence and location of labeled cells within the livers were compared in the magnet group and controls, and confronted with histological analysis representing the standard of reference. Mean iron content per cell was 6 pg. Based on histology, labeled cells were more frequently present within recipient livers in the magnet group (p
- Published
- 2008
21. Assessment of calf muscle contraction by diffusion tensor imaging
- Author
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F. Roudot-Thoraval, N. Paragios, Alain Rahmouni, Guillaume Bassez, Alain Luciani, Hicham Kobeiter, J.-F. Deux, P. Malzy, P. Zerbib, and Alexandre Vignaud
- Subjects
Adult ,Male ,Body water ,Sensitivity and Specificity ,Body Water ,Fractional anisotropy ,Image Interpretation, Computer-Assisted ,medicine ,Effective diffusion coefficient ,Humans ,Radiology, Nuclear Medicine and imaging ,Single-Blind Method ,Muscle, Skeletal ,Leg ,business.industry ,Ultrasound ,Skeletal muscle ,Reproducibility of Results ,General Medicine ,Anatomy ,body regions ,medicine.anatomical_structure ,Diffusion Magnetic Resonance Imaging ,Female ,medicine.symptom ,business ,Tractography ,Diffusion MRI ,Muscle contraction ,Muscle Contraction - Abstract
The goal of this study was to assess the changes of water diffusion during contraction and elongation of calf muscles using diffusion tensor (DT) MRI in normal volunteers. Twenty volunteers (mean age, 29+/-4 years) underwent DT MRI examination of the right calf. Echo planar imaging sequence was performed at rest, during dorsal flexion and during plantar flexion. The three eigenvalues (lambda1, lambda2, and lambda3), apparent diffusion coefficient (ADC) and fractional anisotropy (FA) of the diffusion tensor were calculated for medial gastrocnemius (mGM) and tibialis anterior (TA). A fiber tractography was performed on both muscles. Non-parametric Wilcoxon and Mann Whitney tests were used for statistical evaluation. At rest, lambda1, lambda2 and ADC of mGM were higher than their counterparts of TA (P
- Published
- 2007
22. Evaluation of tumoral enhancement by superparamagnetic iron oxide particles: comparative studies with ferumoxtran and anionic iron oxide nanoparticles
- Author
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Bertrand Bessoud, Pierre-Yves Brillet, Nathalie Siauve, C.A. Cuenod, Florence Gazeau, Poupon J, Alain Luciani, Olivier Clément, and Jean-Noel Pons
- Subjects
Intracellular Fluid ,Male ,medicine.medical_specialty ,Relaxometry ,Biodistribution ,Skin Neoplasms ,media_common.quotation_subject ,Iron ,Kinetics ,Contrast Media ,Mice, Nude ,Adenocarcinoma ,chemistry.chemical_compound ,Mice ,Nuclear magnetic resonance ,In vivo ,medicine ,Tumor Cells, Cultured ,Animals ,Humans ,Radiology, Nuclear Medicine and imaging ,Tissue Distribution ,Internalization ,Magnetite Nanoparticles ,media_common ,business.industry ,Spectrum Analysis ,Electron Spin Resonance Spectroscopy ,Prostatic Neoplasms ,Dextrans ,Extracellular Fluid ,Oxides ,General Medicine ,Image Enhancement ,In vitro ,Ferrosoferric Oxide ,Nanostructures ,Disease Models, Animal ,chemistry ,Spin echo ,Radiology ,Nuclear medicine ,business ,Iron oxide nanoparticles ,Neoplasm Transplantation - Abstract
This study was designed to compare tumor enhancement by superparamagnetic iron oxide particles, using anionic iron oxide nanoparticles (AP) and ferumoxtran. In vitro, relaxometry and media with increasing complexity were used to assess the changes in r2 relaxivity due to cellular internalization. In vivo, 26 mice with subcutaneously implanted tumors were imaged for 24 h after injection of particles to describe kinetics of enhancement using T1 spin echo, T2 spin echo, and T2 fast spin echo sequences. In vitro, the r2 relaxivity decreased over time (0–4 h) when AP were uptaken by cells. The loss of r2 relaxivity was less pronounced with long (Hahn Echo) than short (Carr–Purcell–Meiboom–Gill) echo time sequences. In vivo, our results with ferumoxtran showed an early T2 peak (1 h), suggesting intravascular particles and a second peak in T1 (12 h), suggesting intrainterstitial accumulation of particles. With AP, the late peak (24 h) suggested an intracellular accumulation of particles. In vitro, anionic iron oxide nanoparticles are suitable for cellular labeling due to a high cellular uptake. Conversely, in vivo, ferumoxtran is suitable for passive targeting of tumors due to a favorable biodistribution.
- Published
- 2004
23. Imaging the lymphatic system: possibilities and clinical applications
- Author
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Alain Luciani and Olivier Clément
- Subjects
medicine.medical_specialty ,Contrast Media ,Lymphatic System ,Interstitial fluid ,Medical Illustration ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Ultrasonography, Doppler, Color ,Lymphatic Diseases ,Lymph node ,Neuroradiology ,medicine.diagnostic_test ,business.industry ,Lymphography ,General Medicine ,Sentinel node ,Magnetic Resonance Imaging ,Lymphatic system ,medicine.anatomical_structure ,Positron emission tomography ,Positron-Emission Tomography ,Radiology ,Lymph ,Tomography, X-Ray Computed ,business ,Preclinical imaging - Abstract
The lymphatic system is anatomically complex and difficult to image. Lymph ducts are responsible for the drainage of part of the body's interstitial fluid. Lymph nodes account for the enrichment of lymph fluid, and can be involved in a large variety of diseases, especially cancer. For a long time, lymphatic imaging was limited to the sole use of conventional lymphography involving invasive procedures and patient discomfort. New contrast agents and techniques in ultrasound, nuclear medicine, and MR imaging are now available for imaging of both the lymphatic vessels and the lymph nodes. The objective of this review is to discuss the different imaging modalities of the lymphatic system, with a special focus on the new possibilities of lymphatic imaging including enhanced MR lymphography, sentinel node and positron emission tomography imaging, and contrast-enhanced ultrasound.
- Published
- 2004
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