1. A direct comparison of contrast-enhanced ultrasound and dynamic contrast-enhanced magnetic resonance imaging for prostate cancer detection and prediction of aggressiveness.
- Author
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Baur, Alexander D. J., Schwabe, Julia, Rogasch, Julian, Maxeiner, Andreas, Penzkofer, Tobias, Stephan, Carsten, Rudl, Marc, Hamm, Bernd, Jung, Ernst-Michael, and Fischer, Thom
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ENDORECTAL ultrasonography , *MAGNETIC resonance imaging , *EXOCRINE glands , *CONTRAST-enhanced ultrasound , *BIOPSY , *PROSTATE tumors , *CANCER invasiveness , *COMPARATIVE studies , *ENDOSCOPIC ultrasonography , *RESEARCH methodology , *MEDICAL cooperation , *PROSTATE , *RECTUM , *RESEARCH , *EVALUATION research , *PREDICTIVE tests , *CONTRAST media , *TUMOR grading , *DIAGNOSIS - Abstract
Introduction: Dynamic contrast-enhanced (DCE) magnetic resonance imaging (MRI) and contrast-enhanced ultrasound (CEUS) analyse tissue vascularization. We evaluated if CEUS can provide comparable information as DCE-MRI for the detection of prostate cancer (PCa) and prediction of its aggressiveness.Material and Methods: A post-hoc evaluation of 92 patients was performed. In each patient CEUS and DCE-MRI parameters of the most suspicious lesion identified on MRI were analysed. The predictive values for discrimination between benign lesions, low-/intermediate- and high-grade PCa were evaluated. Results of targeted biopsy served as reference standard (benign lesions, n=51; low- and intermediate-grade PCa [Gleason grade group 1 and 2], n=22; high-grade PCa [≥ Gleason grade group 3], n=19).Results: In peripheral zone lesions of all tested CEUS parameters only time to peak (TTPCEUS) showed significant differences between benign lesions and PCa (AUC 0.65). Of all tested DCE-MRI parameters, rate constant (Kep) was the best discriminator of high-grade PCa in the whole prostate (AUC 0.83) and in peripheral zone lesions (AUC 0.89).Conclusion: DCE-MRI showed a superior performance for detection of PCa and prediction of its aggressiveness. CEUS and DCE-MRI performed better in peripheral zone lesions than in transition zone lesions.Key Points: • DCE-MRI gathers information about vascularization and capillary permeability characteristics of tissues. • DCE-MRI can detect PCa and predict its aggressiveness. • CEUS also gathers information about vascularization of tissues. • For detection of PCa and prediction of aggressiveness DCE-MRI performed superiorly. • Both imaging techniques performed better in peripheral zone lesions. [ABSTRACT FROM AUTHOR]- Published
- 2018
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