1. Fat deposition decreases diffusion parameters at MRI: a study in phantoms and patients with liver steatosis
- Author
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Philippe Garteiser, Valérie Vilgrain, Sabrina Doblas, Gaspard d’Assignies, Bernard E. Van Beers, Carlos F. G. C. Geraldes, Valérie Paradis, Helena S. Leitão, and Jean-Luc Daire
- Subjects
Adult ,Male ,medicine.medical_specialty ,Adipose tissue ,Sensitivity and Specificity ,Statistics, Nonparametric ,Imaging phantom ,030218 nuclear medicine & medical imaging ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Reference Values ,Humans ,Medicine ,Deposition (phase transition) ,Radiology, Nuclear Medicine and imaging ,Aged ,medicine.diagnostic_test ,Phantoms, Imaging ,business.industry ,Ultrasound ,Fatty liver ,Magnetic resonance imaging ,General Medicine ,Middle Aged ,equipment and supplies ,medicine.disease ,Fatty Liver ,Diffusion Magnetic Resonance Imaging ,Adipose Tissue ,Case-Control Studies ,030220 oncology & carcinogenesis ,Female ,Radiology ,Steatosis ,business ,Diffusion MRI - Abstract
Assess the effect of fat deposition on the MRI diffusion coefficients in lipid emulsion-based phantoms and patients with proven isolated liver steatosis.Diffusion-weighted MRI with 11 b values from 0-500 s/mm(2) was performed in phantoms (fat fractions 0-18 %) with and without fat suppression and in 19 patients with normal liver (n = 14) or isolated liver steatosis (n = 5) proven by histopathology. The apparent, pure and perfusion-related diffusion coefficients and the perfusion fraction were measured. Spearman correlation coefficient and Mann-Whitney U test were used for comparisons.A strong correlation between the apparent and pure diffusion coefficients and fat fractions was seen in phantoms. The pure diffusion coefficient decreased significantly in patients with liver steatosis (0.96 ± 0.16 × 10(-3) mm(2)/s versus 1.18 ± 0.09 × 10(-3) mm(2)/s in normal liver, P = 0.005), whereas the decrease in apparent diffusion coefficient did not reach statistical significance (1.26 ± 0.25 × 10(-3) mm(2)/s versus 1.41 ± 0.14 × 10(-3) mm(2)/s in normal liver, P = 0.298).Fat deposition decreases the apparent and pure diffusion coefficients in lipid emulsion-based phantoms and patients with isolated liver steatosis proven by histopathology.
- Published
- 2012
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