1. Dynamic MR imaging of osteoid osteomas: correlation of semiquantitative and quantitative perfusion parameters with patient symptoms and treatment outcome
- Author
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Pedro Augusto Gondim Teixeira, François Sirveaux, Alain Blum, M. Louis, A. Chanson, Marine Beaumont, S. Lecocq, Béatrice Marie, Imagerie Guilloz [CHRU Nancy] (Service d'imagerie Guilloz), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Université de Lorraine (UL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service d’Anatomie Pathologique [CHRU Nancy], Service de Chirurgie Orthopédique, Traumatologique et Arthroscopique [CHRU Nancy] (COTA), and UL, IADI
- Subjects
Male ,Percutaneous ,Tumour recurrence ,030218 nuclear medicine & medical imaging ,0302 clinical medicine ,Recurrence ,Image Processing, Computer-Assisted ,Neuroradiology ,[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology ,Percutaneous laser therapy ,medicine.diagnostic_test ,Ultrasound ,Perfusion magnetic resonance imaging ,Interventional radiology ,General Medicine ,musculoskeletal system ,Magnetic Resonance Imaging ,Perfusion ,Treatment Outcome ,Osteoid osteoma ,030220 oncology & carcinogenesis ,Female ,Patient follow-up ,Radiology ,Laser Therapy ,musculoskeletal diseases ,Adult ,medicine.medical_specialty ,Adolescent ,Osteoma, Osteoid ,Bone Neoplasms ,Sensitivity and Specificity ,03 medical and health sciences ,Young Adult ,Imaging, Three-Dimensional ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,business.industry ,Osteoid ,Lasers ,Magnetic resonance imaging ,medicine.disease ,body regions ,business ,Tomography, X-Ray Computed ,[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology ,Software - Abstract
To evaluate the relationship between multiple MR perfusion parameters and symptoms of patients with osteoid osteomas after percutaneous laser therapy.MR perfusion studies of 20 patients diagnosed with an osteoid osteoma, treated with CT-guided percutaneous laser therapy, were retrospectively evaluated. Multiple perfusion parameters correlated with the treatment outcome and the presence of osteoid osteoma-related symptoms.There were 16 successful treatments, 6 recurrences and a significant difference in the perfusion parameters of these groups (P 0.0001). Patients with successful treatment demonstrated delayed progressive enhancement or no enhancement (mean time to peak = 182 s, mean delay to the arterial peak = 119.3 s). Patients with treatment failure demonstrated an early and steep enhancement (mean time to peak = 78 s and mean delay to the arterial peak = 24 s). Plasmatic volume and transfer constant values significantly changed after successful treatment (P 0.008). MR perfusion has a sensitivity and a specificity higher than 90 % in the detection of recurrent osteoid osteomas.The identification of an early and steep enhancement with short time to peak and a short delay between the arterial and nidus peaks on MR perfusion in the postoperative setting is highly indicative of an osteoid osteoma recurrence. Key points • Magnetic resonance perfusion is becoming widely used for several tumours. • MR perfusion measurements correlate well with osteoid osteoma-related symptoms. • MR perfusion has high diagnostic performance for osteoid osteoma recurrence. • MR perfusion can improve the diagnostic confidence of osteoid osteoma recurrence.
- Published
- 2012
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