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38 results on '"Clare Allen"'

2. Prostate evaluation for clinically important disease: Sampling using image-guidance or not? (The PRECISION study, NCT02380027)

Author

Veeru Kasivisvanathan, Alain Ruffion, Richard Hindley, Jaspal Virdi, Francesco Giganti, J. Hu, Valeria Panebianco, L.A. Mynderse, Franck Bladou, Shonit Punwani, Daniel Margolis, Antti Rannikko, Marcelo Borghi, Clare Allen, Norman R. Williams, Chris Brew-Graves, Wulphert Venderink, Monique J. Roobol, Inderbir S. Gill, A. Freeman, Laurence Klotz, S. Boxler, Samir S. Taneja, Peter A. Pinto, Grégoire Robert, A. Villers, Giles Hellawell, Yemisi Takwoingi, Markku H. Vaarala, Caroline M. Moore, Sebastien Crouzet, Lars Budäus, M. Emberton, Paras B. Singh, Stephen Morris, Boris Hadaschik, M. Ghei, Geert Villeirs, Alberto Briganti, and Scott E. Eggener

Subjects
medicine.medical_specialty, business.industry, Urology, 030232 urology & nephrology, Sampling (statistics), Disease, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, medicine.anatomical_structure, Prostate, Medicine, Medical physics, business, Image guidance
Published
2018
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3. Determining adverse risk factors for urinary continence recovery after robotic radical prostatectomy and methods to enable early recovery

Author

Nicola Pavan, Prasanna Sooriakumaran, A. Kelkar, Prabhakar Rajan, Senthil Nathan, Ashwin Sridhar, Clare Allen, Wei Shen Tan, Greg Shaw, Timothy W. R. Briggs, A. Rawlinson, and D. Gu

Subjects
medicine.medical_specialty, Urinary continence, business.industry, Prostatectomy, Urology, medicine.medical_treatment, Early recovery, Medicine, business
Published
2019
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4. The NeuroSAFE RCT Feasibility Study

Author

Rajendra Persad, Timothy W. R. Briggs, Clare Allen, N. Oakley, A. Haider, Senthil Nathan, Jack Grierson, D. Heffernan-Ho, A. Freeman, Eoin Dinneen, and Greg Shaw

Subjects
medicine.medical_specialty, Randomized controlled trial, business.industry, law, Urology, Physical therapy, Medicine, business, law.invention
Published
2019
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5. NeuroSAFE PROOF: A multi-centre feasibility study to evaluate the ability to randomize men with prostate cancer into an RCT comparing NeuroSAFE robotic-assisted radical prostatectomy (RARP) to standard RARP

Author

Eoin Dinneen, Aiman Haider, Senthil Nathan, N. Oakley, Edward Rowe, Greg Shaw, Timothy W. R. Briggs, Chris Brew-Graves, Rajendra Persad, Clare Allen, and A. Freeman

Subjects
medicine.medical_specialty, business.industry, Prostatectomy, Robotic assisted, Urology, medicine.medical_treatment, medicine.disease, law.invention, Prostate cancer, Randomized controlled trial, law, Medicine, Multi centre, business
Published
2019
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7. MRI as a follow up tool in active surveillance – results from an MRI-defined active surveillance cohort (387 men, median 5 year follow up)

Author

Francesco Giganti, M. Emberton, Clare Allen, Adam Retter, Shonit Punwani, Caroline M. Moore, and Alex Kirkham

Subjects
03 medical and health sciences, Pediatrics, medicine.medical_specialty, 0302 clinical medicine, 5 year follow up, business.industry, 030220 oncology & carcinogenesis, Urology, Cohort, 030232 urology & nephrology, medicine, business
Published
2017
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8. Predicting the predictable: What can we learn from preoperative mpMRI?

Author

Alex Kirkham, O. Alkadhi, D. Heffernan Ho, N. Pavan, Senthil Nathan, Louise Dickinson, James Thompson, Timothy W. R. Briggs, Clare Allen, D. Gu, J. Kelly, Prasanna Sooriakumaran, Ashwin Sridhar, and G. Mazzon

Subjects
medicine.medical_specialty, business.industry, Urology, Medicine, Medical physics, business
Published
2018
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14. 218 Association of level of suspicion of prostate cancer on multi-parametric MRI with detection rate of prostate cancer

Author

Clare Allen, Hashim U. Ahmed, Veeru Kasivisvanathan, Mohamed Abd-Alazeez, M. Emberton, A. Freeman, Susan A. Charman, Robert Dufour, Alex Kirkham, J van der Meulen, and Caroline M. Moore

Subjects
PCA3, Oncology, medicine.medical_specialty, Prostate cancer, Multi parametric, business.industry, Urology, Internal medicine, Medicine, Detection rate, business, medicine.disease
Published
2013
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15. 717 Transperineal MRI-targeted biopsy versus transperineal template prostate mapping biopsy in the detection of localised radio-recurrent prostate cancer

Author

Manit Arya, Hashim U. Ahmed, Abi Kanthabalan, Shonit Punwani, Alex Freeman, Mohammed Abl-Azzeez, Mark Emberton, Clare Allen, and Alex Kirkham

Subjects
medicine.medical_specialty, medicine.anatomical_structure, medicine.diagnostic_test, business.industry, Prostate, Urology, Biopsy, Medicine, Recurrent prostate cancer, business, Targeted biopsy
Published
2013
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18. PE38: Introduction of a 'dedicated prostate surgical planning meeting' increases the frequency of nerve-sparing in men undergoing robotic prostatectomy for prostate cancer while maintaining oncological safety

Author

J. Kelly, Senthil Nathan, John Hines, Tim Briggs, Clare Allen, Ashwin Sridhar, G. Basnett, Alex Kirkham, Navin Ramachandran, M. Goldstraw, Paul Cathcart, and Miles Walkden

Subjects
medicine.medical_specialty, Prostate cancer, Nerve sparing, medicine.anatomical_structure, business.industry, Prostate, Urology, Medicine, business, Robotic prostatectomy, medicine.disease, Surgical planning
Published
2014
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20. 585 Focal therapy targeted to the index lesion in multifocal prostate cancer: A prospective development study

Author

Hashim U. Ahmed, J van der Meulen, Neil McCartan, Clare Allen, M. Sahu, A. Freeman, Shraddha Weir, Alex Kirkham, Susan A. Charman, M. Emberton, R. Hindley, and C.L. Dickinson

Subjects
Oncology, Focal therapy, medicine.medical_specialty, Prostate cancer, Index Lesion, business.industry, Urology, Internal medicine, Medicine, business, medicine.disease
Published
2013
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22. 1096 The natural history of untreated prostate MRI lesions in an active surveillance prostate cancer population – 260 patient-years

Author

J van der Meulen, Alex Kirkham, Caroline M. Moore, Daniel Stevens, Hashim U. Ahmed, M. Emberton, and Clare Allen

Subjects
medicine.medical_specialty, education.field_of_study, business.industry, Urology, Population, medicine.disease, Natural history, Prostate cancer, medicine.anatomical_structure, Prostate, medicine, education, business
Published
2012
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23. 795 What burden of prostate cancer can radiologists rule-out on multi-parametric MRI? An analysis based on template prostate mapping biopsies as the reference standard

Author

A. Freeman, M. Emberton, S.A. Sohaib, Alex Kirkham, Clare Allen, Hashim U. Ahmed, and Nimalan Arumainayagam

Subjects
medicine.medical_specialty, Prostate cancer, medicine.anatomical_structure, Multi parametric, Prostate, business.industry, Urology, medicine, Radiology, business, medicine.disease, Reference standards
Published
2012
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25. 893 TRIFECTA OUTCOMES AFTER WHOLE-GLAND HIGH INTENSITY FOCUSED ULTRASOUND FOR THE TREATMENT OF LOCALISED PROSTATE CANCER: A REGISTRY-BASED ANALYSIS

Author

Caroline M. Moore, Paul Cathcart, Neil McCartan, A. Freeman, Clare Allen, Hashim U. Ahmed, Louise Dickinson, Alex Kirkham, and M. Emberton

Subjects
Gynecology, medicine.medical_specialty, Prostate cancer, business.industry, Urology, medicine.medical_treatment, medicine, Radiology, business, medicine.disease, High-intensity focused ultrasound
Published
2011
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26. 936 TOOKAD ® SOLUBLE (PADELIPORFIN) SECOND GENERATION VASCULAR TARGETED PHOTODYNAMIC THERAPY (VTP) FOR PROSTATE CANCER: SAFETY AND FEASIBILITY

Author

Caroline M. Moore, Luc Cormier, A. Villers, Richard Hindley, Gordon Muir, M. Emberton, Clare Allen, Abdel-Rahmène Azzouzi, Neil Barber, Eric Barret, Nimalan Arumainayagam, and John Trachtenberg

Subjects
Oncology, medicine.medical_specialty, Prostate cancer, business.industry, Padeliporfin, Urology, medicine.medical_treatment, Internal medicine, Medicine, Photodynamic therapy, business, medicine.disease
Published
2010
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28. 712 MULTI-PARAMETRIC MAGNETIC RESONANCE IMAGING (MP-MRI) AND LOCALISATION OF SIGNIFICANT PROSTATE CANCER: CAN IT BE USED AS A TRIAGE TOOL?

Author

Hashim U. Ahmed, Clare Allen, Alex Kirkham, A. Freeman, Caroline M. Moore, Aslam Sohaib, M. Emberton, and N. Arumainavagam

Subjects
Prostate cancer, medicine.medical_specialty, Multi parametric, medicine.diagnostic_test, business.industry, Urology, medicine, Magnetic resonance imaging, Radiology, business, medicine.disease, Triage
Published
2010
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29. 806 THE VALUE OF MAGNETIC RESONANCE IMAGING AND PSA IN DETECTING RECURRENCE AFTER HIGH INTENSITY FOCUSED ULTRASOUND

Author

Miles Walkden, Alex Kirkham, Aslam Sohaib, Clare Allen, M. Emberton, A. Freeman, and Shonit Punwani

Subjects
medicine.medical_specialty, Nuclear magnetic resonance, medicine.diagnostic_test, business.industry, Urology, medicine.medical_treatment, medicine, Magnetic resonance imaging, Medical physics, business, Value (mathematics), High-intensity focused ultrasound
Published
2009
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30. 855 HIGH INTENSITY FOCUSED ULTRASOUND (HIFU) HEMIABLATION TRIAL IN LOCALISED UNILATERAL PROSTATE CANCER: INTERIM RESULTS

Author

Alex Kirkham, M. Sahu, Nimalan Arumainayagam, Clare Allen, Hashim U. Ahmed, R. Scott, Rowland Illing, J van der Meulen, M. Emberton, A. Freeman, and S.K. Govindaraju

Subjects
Gynecology, medicine.medical_specialty, Prostate cancer, business.industry, Urology, Interim, medicine.medical_treatment, Medicine, Radiology, business, medicine.disease, High-intensity focused ultrasound
Published
2009
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31. THE ROLE OF TRANSPERINEAL TEMPLATE PROSTATE MAPPING BIOPSIES IN RISK-STRATIFYING MEN WITH LOCALISED PROSTATE CANCER

Author

Mark Emberton, Daniel Stevens, Evangelos Zacharakis, Rowland Illing, Hashim U. Ahmed, A. Freeman, O. Barbouti, Clare Allen, and Douglas Pendse

Subjects
Gynecology, Oncology, medicine.medical_specialty, Prostate cancer, medicine.anatomical_structure, business.industry, Prostate, Urology, Internal medicine, medicine, business, medicine.disease
Published
2008
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32. DYNAMIC CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING AFTER VASCULAR-TARGETED PHOTODYNAMIC THERAPY (VTP) WITH TOOKAD (PADOPORFIN) IN PRIMARY PROSTATE CANCER

Author

Alex Kirkham, Hashim U. Ahmed, Mark Emberton, Clare Allen, Stephen G. Bown, Douglas Pendse, and Caroline M. Moore

Subjects
medicine.medical_specialty, medicine.diagnostic_test, business.industry, Urology, medicine.medical_treatment, Magnetic resonance imaging, Photodynamic therapy, medicine.disease, Dynamic contrast, Prostate cancer, medicine, Medical physics, Radiology, business
Published
2008
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33. 707 HIGH INTENSITY FOCUSED ULTRASOUND (HIFU) FOR LOCALIZED PROSTATE CANCER (T1–2, NO, M0): INTRA-PROCEDURE DETERMINANTS OF BIOPSY PROVEN FAILURE USING THE SONOBLATE© 500 SYSTEM

Author

Hashim U. Ahmed, James E. Kennedy, A. Freeman, R. Iling, Simon Brewster, Tom Leslie, M. Emberton, J. Calleary, and Clare Allen

Subjects
medicine.medical_specialty, Prostate cancer, medicine.diagnostic_test, business.industry, Urology, medicine.medical_treatment, Biopsy, medicine, Radiology, medicine.disease, business, High-intensity focused ultrasound
Published
2007
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35. A CLINICAL EVALUATION OF THE OPTICAL CHARACTERISTICS OF THE PROSTATE IN MEN WITH PROSTATE CANCER

Author

Heather Payne, Caroline M. Moore, Clare Allen, I Hoh, Charles A. Mosse, Stephen G. Bown, and M. Emberton

Subjects
medicine.medical_specialty, business.industry, Urology, medicine.medical_treatment, Ultrasound, medicine.disease, Laser, High-Dose Rate Brachytherapy, law.invention, Surgery, Radiation therapy, Prostate cancer, Light intensity, medicine.anatomical_structure, law, Prostate, medicine, business, Penetration depth, Nuclear medicine
Abstract

Introduction & Objectives The use of lasers is becoming increasingly common in urology, particularly in the prostate. Low power laser is used in photodynamic therapy in order to activate a photosensitising drug. The extent of the photodynamic effect is dependent upon the optical characteristics of the prostate. These characteristics, which encompass both scattering and absorption, can be expressed as the depth of penetration of the laser energy. We report a study using 763nm light to assess variability in laser penetration depth throughout the prostate. Material & Methods The study was carried out in patients having high dose rate brachytherapy (HDRB). These patients have up to 22 hollow clear plastic needles in the prostate for 36 hours. The needles are inserted under general anaesthetic, using transrectal ultrasound and a perineal template. A CT scan is taken once the patient is awake, and the radiotherapy dose is planned by the radiotherapy medical and physics team. The radiotherapy dose is given by sliding an iridium wire along each needle, which rests at different positions along the needle for different times. The doses are given 6, 24 and 30 hours after needle placement. Prior to the first radiotherapy dose, we used the needles to position optical delivery and detection fibres in multiple positions throughout the prostate. A 763 nm laser was used to deliver light via a 2cm diffusing fibre. An isotropic optical detector was slid along nearby needles, and optical readings taken every 6mm. The exact separation distance of the delivery and detector fibre at each of the optical measurement positions was then measured on different slices of the CT scan. The Boltzmann approximation to the transport equation was used to calculate the penetration depth (PD), which is defined as the depth at which 63% of light intensity is lost. Results Over 1000 data points in 8 patients were assessed. The mean PD was 3.7 mm with a range of 1.35 - 33 mm. The PD varied within patients by up to a factor of up to 12 times, with the mean variation within an individual patient of 4 times. Between patient variability of the PD was not as significant as intra patient variability. From examination of the CT scans of the patients it was not possible to identify any factors which would predict PD. Conclusions This study shows that there is marked variability of laser penetration both within and between patients with prostate cancer. It will be important to see if this translates to a difference in therapeutic effect in treatments which use lasers, in this patient group.

Published
2006
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38. VASCULAR-TARGETED PHOTODYNAMIC THERAPY IN ORGAN CONFINED PROSTATE CANCER -REPORT OF A NOVEL PHOTOSENSITISER

Author

M. Emberton, Caroline M. Moore, Clare Allen, A. Freeman, I Hoh, Charles A. Mosse, and Stephen G. Bown

Subjects
medicine.medical_specialty, Necrosis, business.industry, Urology, medicine.medical_treatment, Rectum, Photodynamic therapy, medicine.disease, Surgery, Prostate cancer, Urethra, medicine.anatomical_structure, Prostate, Dynamic contrast-enhanced MRI, medicine, medicine.symptom, Phototoxicity, Nuclear medicine, business
Abstract

Introduction & Objectives Photodynamic Therapy (PDT) uses a photosensitising drug, activated by single wavelength light from a laser to cause localised necrosis. Tookad is a vascular acting photosensitiser which is activated by 763 nm light. It has a short drug light interval, so that both drug and light are given in a single session. Due to rapid clearance, it has no skin phototoxicity after 3 hours. Vascular-Targeted Photodynamic therapy (VTP) with Tookad (WST09) has been evaluated in patients with post-radiotherapy prostate cancer recurrence. Here we report the use of Tookad VTP in the previously untreated prostate. The effect of different light doses with a constant drug dose was evaluated using gadolinium-enhanced MRI at 1 week. Material & Methods Under general anaesthetic, using transrectal ultrasound guidance and a perineal template, two hollow, clear plastic needles were inserted into each of the right and left lobes of the prostate. On each side, the needles held one optical delivery fibre, and one optical detection fibre. Optical detectors were also placed within catheters in the urethra and rectum to monitor light levels throughout the light delivery phase. Once needle positions were finalised, an infusion of 2 mg/kg Tookad was given over 20 minutes. After the infusion began, the light dose was given. The light dose was escalated throughout the study, with a minimum of 50 J/cm, and a maximum of 300 J/cm at a power of either 150 or 200 mW. The active length of the diffuser was chosen to leave a 5 mm margin at the base and apex of the prostate. A dynamic gadolinium-enhanced MRI was performed prior to and 1 week after the VTP procedure. PSA was measured prior to and at 1, 3 and 6 months after VTP. Results Eleven men have undergone the Tookad VTP procedure and 1 week MRI to date. Prostate tissue necrosis, seen as absence of uptake of gadolinium, was observed in men receiving a light dose of 150 J/cm or more. The volume of necrosis varied with the light dose per cm, and the total light dose, but all patients had a PSA reduction at 1 or 3 months. All patients had a successful catheter removal the day after Tookad VTP, with four experiencing transient irritative urinary symptoms. Nine patients had a transient elevation of gamma GT and transaminases which resolved spontaneously within two weeks. Conclusions The Tookad VTP procedure is a promising minimally invasive treatment for prostate cancer. It can cause necrosis, as shown by lack of uptake of gadolinium on dynamic MRI at 1 week. This is accompanied by a PSA reduction. The procedure itself is safe and well tolerated. The study will continue using multiple optical fibres in each lobe.

Published
2006
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