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OBJECTIVE: To explore the effects of Shenmai injection on heart function, serum N-terminal B-type natriuretic peptide (NT-proBNP) and hypersensitive cardiac troponin T (hs-cTnT) in elderly patients with advanced breast cancer at heart failure stage. METHODS: Totally 94 patients with advanced breast cancer at heart failure stage admitted into Shanghai Baoshan Integrated Hospital of Traditional Chinese and Western Medicine from Jun. 2018 to Dec. 2019 were extracted to be divided into the control group (n = 47) and the observation group (n = 47) via the random number table. The control group received conventional symptomatic treatment, while the observation group was treated with Shenmai injection on the basis of the control group. Clinical efficacy, changed of cardiac function such as left ventricular ejection fraction (LVEF), cardiac output (CO), early diastolic maximum flow velocity/ late diastolic maximum flow velocity (E/ A), serum creatine kinase isoenzyme (CK-MB), creatine kinase (CK), NT-proBNP and hs-cTnT levels before and after treatment were observed in two groups. RESULTS: After treatment, the total effective rate of the observation group was 87. 23% (41/47), significantly higher than 65. 96% (31/47) of the control group, the difference was statistically significant (P<0. 05). After treatment, the levels of LVEF, ratio of CO and E/ A in two groups increased significantly, and the observation group was significantly better than the control group, with statistically significant difference (P<0. 05). After treatment, the levels of CK-MB, CK, NT-proBNP and hs-cTnT in two groups decreased significantly, and the improvement in the observation group was better than that in the control group, with statistically significant difference ( P < 0. 05). CONCLUSIONS: Shenmai injection can significantly improve the cardiac function of elderly patients with advanced breast cancer by increasing the myocardial contractility and the anti-lipid peroxidation, reducing the risk of myocardial injury and heart failure and improving the clinical efficiency. [ABSTRACT FROM AUTHOR]