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OBJECTIVE: To probe into the clinical efficacy of cocktail neuroprotective agents(N6) in treatment of spasm in patient with traumatic spinal cord injury (TSCI). METHODS: 189 patients with TSCI diagnosed by Jinan Military General Hospital from Jan.2013 to Jun.2016 were retrospectively selected and divided into observation group (102 cases) and control group(87 cases) according to the application of cocktail neuroprotective agents(N6). The incidence of spasm of two groups were observed and compared at 2 months and 12 months after injured;for patients stricken by spasm at 2 months after injured, the total effective rate at 12 months after injured were observed and compared. RESULTS: At 2 months and 12 months after injured, the incidence of spasm of the observation group was significantly lower than that of the control group, with statistically significant difference (P ＜ 0.05). 12 months after injured,the total effective rate of the observation group (62.79％, 27/43) was significantly higher than that of the control group(35.85％, 19/53), with statistically significant difference(P ＜0.05). CONCLUSIONS: The cocktail neuroprotective agents(N6) can effectively reduce the incidence of spasm in patient with TSCI, with high cure rate. [ABSTRACT FROM AUTHOR]