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OBJECTIVE: To probe into the safety and efficacy of non-intubated general anesthesia with remimazolam combined with remifentanil in AngioJet mechanical thrombectomy for lower extremity deep vein thrombosis. METHODS: Totally 120 patients who underwent AngioJet mechanical thrombectomy for lower extremity deep vein thrombosis in Linyi People’s Hospital from Oct. 2021 to Oct. 2023 were extracted to be divided into the non-intubated general anesthesia group (n =60) and awake sedation group (n =60) through the random number table method. The non-intubated general anesthesia group received remimazolam combined with remifentanil for non intubated general anesthesia, while the awake sedation group was given awake sedation anesthesia. Vital signs of two groups of patients, including systolic blood pressure (SBP), diastolic blood pressure (DBP), cardiac output (CO), systemic vascular resistance (SVR), stroke volume and heart rate were compared at at the time of admission (T1), target vessel puncture (T2), drug spraying (T3), 15 minutes after drug spraying (T4 ), thrombus aspiration (T5), and 5 minutes after surgery (T6), 1 hour after surgery (T7), 4 hours after surgery (T8), and 12 hours after surgery (T9). The use of antihypertensive drugs during and after surgery, occurrence of hematuria and adverse events, target vessel puncture time, patients’ satisfaction score, and clinicians’ satisfaction score were recorded and compared between two groups. RESULTS: (1) From T1 to T9, there were statistically significant differences within the SBP and DBP groups between the non-intubated general anesthesia group and awake sedation group (P<0. 001). Both groups showed an increase in SBP and DBP at T3 and returned to normal at T9. The non-intubated general anesthesia group showed a significant decrease in SBP and DBP from T2 to T5 compared with the awake sedation group, with statistically significant difference (P<0. 001). (2) From T1 to T6, there were statistically significant differences with SVR and CO groups between the non-intubated general anesthesia group and awake sedation group (P<0. 001). SVR increased in both groups from T3 to T6, while CO decreased in both groups from T2 to T5. At various time points from T2 to T6, SVR of the non-intubated general anesthesia group was significantly lower than that of the awake sedation group, with statistically significant difference (P<0. 05). At various time points from T3 to T6, CO in the non-intubated general anesthesia group were significantly higher than those in the awake sedation group, with statistically significant difference (P<0. 05). (3) The clinicians’ satisfaction score and patients’ satisfaction score in the non-intubation general anesthesia group were significantly higher than those in the wake sedation group, with statistically significant differences ( P < 0. 001). (4) The use rate of antihypertensive drugs during surgery, the incidence of body movements, the incidence of severe hypertension and hypertensive subacute disease during surgery in the non-intubated general anesthesia group were significantly lower than those in the wake sedation group, with statistically significant differences (P < 0. 001). CONCLUSIONS: Remazolam combined with remifentanil for non-intubation general anesthesia has good safety and efficacy in AngioJet mechanical thrombectomy for lower extremity deep vein thrombosis [ABSTRACT FROM AUTHOR]

OBJECTIVE: To probe into the efficacy of Danhong injection combined with dabigatran etexilate in preventing lower limb venous thrombosis after surgery of lower limb fracture. METHODS: 176 patients undergoing surgery of lower limb fracture admitted into Traditional Chinese Medicine Hospital of Jiangxia District from Dec. 2017 to Jun. 2018 were selected and divided into observation group and control group via random number table, with 88 cases in each group. The control group was treated with dabigatran etexilate, while the observation group was given Danhong injection combined with dabigatran etexilate. Differences in clinical efficacy, coagulation function indices [prothrombin lime (PT), activated partial thrombin lime (APTT) and D-dimer (D-D)], hemorheology indices and incidences of adverse drug reactions between two groups were compared. RESULTS:The total effective rate of observation group was 94.32% (83/88), which was significantly higher titan that of the control group (76.14%, 67/88), with statistically significant difference(P<0.05). Alter treatment, the PT and APTT levels of both groups had been significantly prolonged, with significantly lower D-D levels, and the above indices of observation group were significantly better than those of the control group, with statistically significant differences(P<0.05). Alter treatment, the whole blood low shear viscosity, whole blood high shear viscosity, plasma viscosity and fibrinogen level of both groups were significantly lower than those of before treatment, and the above indices of observation group were significantly better than the control group, with statistically significant dilferences(P<0.05). Both of the incidences of adverse drug reactions of both groups were 5.68% (5/88), the difference had no statistical significance (P>0.05). CONCLUSIONS: Danhong injection combined with dabigatran etexilate can effectively reduce the incidences of lower limb venous thrombosis alter surgery of lower limb fracture, which can improve hypercoagulable state, with safety and effectiveness. [ABSTRACT FROM AUTHOR]

目的:探讨下肢深静脉血栓经介入治疗的临床效果.方法:从我院２０１４年１月~２０１５年６月收治的下肢深静脉血栓患者中随机选取５８ 例进行研究,所有患者均行介入治疗,并评价其治疗效果以及治疗前后的临床症状改善情况.结果:①本次患者共有７例治愈,约占１２．０７％;３４ 例显效,约占５８．６２％;１４例有效,约占２４．１４％;３例无效,约占５．１７％,总有效率为９４．８３％.同时,治疗前后大腿和小腿的周径差差异具有统计学 意义(P＜０．０５).②治疗前,静脉通畅率的评分为(９．４２±２．６９)分,治疗后则为(４．５５±２．２２)分,治疗前后差异显著,具有统计学意义(P＜０．０５).结 论:下肢深静脉血栓经介入治疗具有显著的临床效果,而且安全有效,值得进行临床推广. [ABSTRACT FROM AUTHOR]