1. Acute and Subacute Oral Toxicity Evaluation of Eriobotrya japonica Leaf Triterpene Acids in ICR Mice.
- Author
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Li, Feng, Li, Yijia, Li, Qingxian, Shi, Xianai, and Guo, Yanghao
- Subjects
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ANIMAL experimentation , *BIOCHEMISTRY , *BLOOD testing , *BODY weight , *HISTOLOGICAL techniques , *MICE , *MOLECULAR structure , *SAFETY , *TOXICITY testing , *PLANT extracts - Abstract
The interest focusing on Eriobotrya japonica leaf triterpene acid (ELTA) has increased recently because of its beneficial effects on health. However, there has been a lack of experimental data on its toxicity. The present study therefore was conducted to evaluate its toxicity in ICR mice. The results showed that ELTA produced neither mortality nor toxicity of the main organs in ICR male and female mice in both acute (0.30, 0.65, 1.39, and 3.00 g·kg−1 body weight) and subacute (150, 300, and 600 mg·kg−1 BW) 28-day toxicity studies. Because of lacking apparently adverse effects found in the hematology, clinical biochemistry, and histopathology evaluation, results of the present study together with the beneficial effects make ELTA as a promising dietary supplement and indicated that ELTA administered orally might have a large safety margin for human. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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