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Start Over Author "Guo, Jian" Search Limiters Peer Reviewed Topic cell differentiation Topic cellular signal transduction Journal evidence-based complementary & alternative medicine (ecam)

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2 results on '"Guo, Jian"'

1. Lycium barbarum Polysaccharide Ameliorates Heat-Stress-Induced Impairment of Primary Sertoli Cells and the Blood-Testis Barrier in Rat via Androgen Receptor and Akt Phosphorylation.

Author

Hu, Suqin, Liu, Dianlong, Liu, Sijia, Li, Chunrui, and Guo, Jian

Subjects
*POLYSACCHARIDES, *TESTIS, *BIOLOGICAL models, *CELL differentiation, *MEDICINAL plants, *PHYSIOLOGICAL effects of heat, *ANIMAL experimentation, *CELL physiology, *INFERTILITY, *CELLULAR signal transduction, *RATS, *TRANSFERASES, *CELL proliferation, *EPITHELIAL cells, *ANDROGEN receptors, *MOLECULAR structure, *CHINESE medicine, *PHOSPHORYLATION
Abstract

Male infertility induced by heat stress has been attracting more and more attention. Heat stress not only causes apoptosis of spermatocytes but also has adverse effects on Sertoli cells, further damaging spermatogenesis. Lycium barbarum polysaccharide (LBP) is the main bioactive component of Lycium barbarum, which has a protective effect on male reproduction, but its mechanism is still unclear. In this study, our results proved that LBP blocked the inhibitory effect on the proliferation activity of Sertoli cells after heat stress, reversed the dedifferentiation of Sertoli cells induced by heat stress, and ameliorated the structural integrity of the blood-testis barrier. In addition, it increased the expression of the androgen receptor and activated Akt signaling pathway to resist heat-stress-induced injury of Sertoli cells. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
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2. Lycium barbarum Polysaccharide Ameliorates Heat-Stress-Induced Impairment of Primary Sertoli Cells and the Blood-Testis Barrier in Rat via Androgen Receptor and Akt Phosphorylation.

Author

Hu, Suqin, Liu, Dianlong, Liu, Sijia, Li, Chunrui, and Guo, Jian

Subjects
*POLYSACCHARIDES, *TESTIS, *CELL differentiation, *MEDICINAL plants, *HERBAL medicine, *PHYSIOLOGICAL effects of heat, *ANIMAL experimentation, *CELL physiology, *INFERTILITY, *CELLULAR signal transduction, *RATS, *TRANSFERASES, *CELL proliferation, *EPITHELIAL cells, *ANDROGEN receptors, *CHINESE medicine, *PHOSPHORYLATION
Abstract

Male infertility induced by heat stress has been attracting more and more attention. Heat stress not only causes apoptosis of spermatocytes but also has adverse effects on Sertoli cells, further damaging spermatogenesis. Lycium barbarum polysaccharide (LBP) is the main bioactive component of Lycium barbarum, which has a protective effect on male reproduction, but its mechanism is still unclear. In this study, our results proved that LBP blocked the inhibitory effect on the proliferation activity of Sertoli cells after heat stress, reversed the dedifferentiation of Sertoli cells induced by heat stress, and ameliorated the structural integrity of the blood-testis barrier. In addition, it increased the expression of the androgen receptor and activated Akt signaling pathway to resist heat-stress-induced injury of Sertoli cells. [ABSTRACT FROM AUTHOR]

Published
2021
Full Text
View/download PDF

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