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Made available in DSpace on 2018-11-26T17:06:36Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-01-01 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) The Brazilian forests have one of the world's biggest biodiversities. Achyrocline satureioides (macela) and Acmella oleracea (jambu) are native species from Brazil with a huge therapeutic potential, with proved anti-inflammatory and anesthetic action, respectively. The jambu's crude extract after depigmentation with activated charcoal and macela's essential oil were incorporated in a film made with hydroxyethyl cellulose. Those films were evaluated by mechanical test using a texturometer and anti-inflammatory and anesthetic activities by in vivo tests: wound healing and antinociceptive. The film containing the highest concentration of depigmented jambu's extract and macela's essential oil obtained an anesthesia time of 83.6 (+/- 28.5) min longer when compared with the positive control EMLA (R); the same occurred with the wound healing test; the film containing the highest concentration had a higherwound contraction (62.0%+/- 12.1) compared to the positive control allantoin and the histopathological analysis demonstrated that it increases collagen synthesis and epidermal thickening. The results demonstrate that the films have a potential use in skin wounds, pressure sore, and infected surgical wounds treatment. Univ Estadual Campinas, Chem Biol & Agr Res Ctr CPQBA, Campinas, SP, Brazil Univ Estadual Campinas, Dept Biochem & Tissue Biol, Biol Inst, Campinas, SP, Brazil Sao Paulo State Univ, Inst Biosci, Dept Biol, Rio Claro, SP, Brazil Sao Paulo State Univ, Inst Biosci, Dept Biol, Rio Claro, SP, Brazil FAPESP: 2016/13776-5