1. Antiulcerogenic Activity of the Hydroalcoholic Extract of Leaves of Croton campestris A. St.-Hill in Rodents
- Author
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Ana Luiza de Albuquerque Siebra, Anita Oliveira Brito Pereira Bezerra Martins, Dayanne Rakelly de Oliveira, José Galberto Martins da Costa, Valterlúcio dos Santos Sales, Érika do Nascimento Amaro, Laura Hévila Inocêncio Leite, Emmily Petícia do Nascimento, Andreza Guedes Barbosa Ramos, Irwin Rose Alencar de Menezes, C. K. Rodrigues, Álefe Brito Monteiro, Larissa Rolim de Oliveira, Renata de Souza Sampaio, Elizângela B. Bento, Henrique Douglas Melo Coutinho, Luiz J. Lacerda-Neto, Francisco Rodolpho Sobreira Dantas Nóbrega de Figuêiredo, Patrícia Rosane Leite de Figueiredo, Francisco Elizaudo de Brito Junior, Saulo R. Tintino, Marta Regina Kerntopf, and Daniele Oliveira Souza
- Subjects
Article Subject ,Traditional medicine ,biology ,business.industry ,Northeast brazil ,Gastric lesions ,Biological potential ,lcsh:Other systems of medicine ,biology.organism_classification ,lcsh:RZ201-999 ,Croton ,Intestinal motility ,Health problems ,Complementary and alternative medicine ,Natural source ,Medicine ,Gastritis ,medicine.symptom ,business ,Research Article - Abstract
Croton campestrisA. St.-Hill., popularly known as “velame do campo,” is a species native to the savannah area of Northeast Brazil, which is used by traditional communities in folk medicine for variety of health problems, especially detoxification, inflammation, and gastritis. The hydroalcoholic extract ofC. campestrisleaves (HELCC) was assessed for its antiulcerogenic effect in gastric lesion models and effect on intestinal motility in mice, and possible mechanisms of action were examined. HELCC showed significant gastroprotective action in all models of gastric ulcer evaluated; the results suggest that this action probably involves the nitric oxide pathway. HELCC did not show alteration of intestinal motility in mice. It was also found thatC. campestrisrepresents a promising natural source with important biological potential, justifying some of its uses in folk medicine.
- Published
- 2013