1. PGC-1alpha gene and physical activity in type 2 diabetes mellitus.
- Author
-
Franks PW and Loos RJ
- Subjects
- Base Sequence, Gene Expression Regulation, Genetic Variation, Glucose metabolism, Humans, Oxygen Consumption genetics, Oxygen Consumption physiology, Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha, RNA, Messenger physiology, Diabetes Mellitus, Type 2 genetics, Diabetes Mellitus, Type 2 physiopathology, Heat-Shock Proteins genetics, Motor Activity physiology, Transcription Factors genetics
- Abstract
Exercise stimulates PGC-1alpha gene expression and increases V O2max, the latter of which relates inversely with type 2 diabetes risk. Consistently, low levels of PGC-1alpha mRNA and nucleotide sequence variation at PGC-1alpha associate with lower level of V O2max and increased diabetes risk. Thus, PGC-1alpha sequence variation may interact with physical activity to modify diabetes risk via changes in oxidative energy metabolism.
- Published
- 2006
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