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Plasma catecholamines are increased in sodium-loaded rats under both resting and stress conditions. Under stress, Na resistant rats have lower plasma catecholamines than salt-sensitive ones. [ABSTRACT FROM AUTHOR]

The cardiac catecholamine content of Sabra rats and their 2 genetically derived substrains, hypertension prone and resistant rats, was studied by high pressure liquid chromatography and electrochemical detection. Both in the control period and after sodium and DOCA administration the cardiac noradrenaline level is higher in hypertension resistant rats than in Sabra rats, and also higher than in hypertension prone rats. This finding suggests that a reduction of the cardiac sympathetic nervous tone is involved in the genetic resistance to sodium. [ABSTRACT FROM AUTHOR]