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3. Prostaglandin production by human polymorphnuclear leucocytes during phagocytosis in vitro

Author

L Bonasera, C Tolone, G. Tolone, M Brai, Tolone, G, Bonasera, L, Brai, M, and Tolone, Carlo

Subjects
Pharmacology, Polymorphonuclear leukocyte, Neutrophils, Phagocytosis, medicine.medical_treatment, Prostaglandins E, Zymosan, Prostaglandin production, Prostaglandin, Cell Biology, In Vitro Techniques, In vitro, Microbiology, Cellular and Molecular Neuroscience, chemistry.chemical_compound, chemistry, Immunology, medicine, Molecular Medicine, Humans, Molecular Biology, Prostaglandin E
Abstract

Human polymorphonuclear leukocytes were found to be able to synthetize and release substantial amounts of PGE2' when stimulated by a phagocytic stimulus such as zymosan particles coated with complement. Hydrocortisone, at a concentration of 10(-5) M, which proved to be effective in other biological systems, failed to inhibit phagocytosis and PG release.

Published
1977

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