1. The biogenesis, biological functions and modification of Circular RNAs.
- Author
-
Liu, Sen, Guo, Xiang Yu, Shang, Qing Juan, and Gao, Peng
- Subjects
- *
CIRCULAR RNA , *RNA modification & restriction , *TRIGONOMETRIC functions , *BASE pairs , *NUCLEOTIDE sequencing , *ADENOSINES - Abstract
Circular RNAs are covalently closed and non-coding in eukaryotes, which have tissue- specific and temporal-specific expression patterns whose biogenesis is regulated by transcription and splicing. Most circular RNAs are localized in the cytoplasm. The sequences and protein-binding elements of circular RNAs facilitate circular RNAs in exerting biological functions through complementary base pairing, regulating protein function or self-translation. Recent studies have revealed that N6-Methyladenosine (m6A), a prevalent post-transcriptional modification, can affect the translation, localization, and degradation of circular RNAs. Cutting-edge research into circular RNAs have benefitted from the development of high-throughput sequencing technology. Furthermore, the expansion of novel research methods has promoted progress into circular RNA research. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF