1. Effects of Commonly Used Antidiabetic Drugs on Antioxidant Enzymes and Liver Function Test Markers in Type 2 Diabetes Mellitus Subjects – Pilot Study
- Author
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Prabhakar K. Ranjekar, Abhijit A. Ghadge, Omkar Kulkarni, Suresh Khadke, Arundhati Diwan, Aniket Kuvalekar, Shubhangi Harke, Abhay Harsulkar, and Madhu Pankaj
- Subjects
Adult ,Male ,medicine.medical_specialty ,endocrine system diseases ,Bilirubin ,Endocrinology, Diabetes and Metabolism ,medicine.medical_treatment ,Pilot Projects ,Antioxidants ,Transaminase ,chemistry.chemical_compound ,Endocrinology ,Insulin resistance ,Diabetes mellitus ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Insulin ,medicine.diagnostic_test ,Superoxide Dismutase ,business.industry ,nutritional and metabolic diseases ,Alanine Transaminase ,General Medicine ,Middle Aged ,medicine.disease ,Metformin ,Diabetes Mellitus, Type 2 ,Liver ,chemistry ,Homeostatic model assessment ,Drug Therapy, Combination ,Female ,Insulin Resistance ,business ,Liver function tests ,medicine.drug - Abstract
OBJECTIVE The present study analyzed the effects of antidiabetic drugs on antioxidant enzymes and liver function test (LFT) markers and their association with homeostatic model assessment of insulin resistance (HOMA-IR) in type 2 diabetic subjects. METHODS We assessed healthy and diabetic subjects (100 each). Diabetic subjects were divided based on treatment with only metformin, metformin in combination with other antidiabetic drugs and insulin in combination with other antidiabetic drugs. LFT markers, antioxidant status and HOMA-IR were assessed in the subjects. RESULTS Superoxide dismutase activity was higher (p
- Published
- 2015
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