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Your search keyword '"Shinya Kohno"' showing total 2 results
Start Over Author "Shinya Kohno" Journal experimental animals
2 results on '"Shinya Kohno"'

1. Effect of Insulin-Like Growth Factor-I(IGF-I) on Femoral Bone Modeling in Growing Mice

Author

Junji Ohtani, Tadashi Fujita, Kaoru Tenjo, Kazuo Tanne, C Tokimasa, Shinya Kohno, Keisuke Tsutsui, Masato Kaku, Akira Matsuki, Mao Shigekawa, Toshitsugu Kawata, Takashi Kobayakawa, and Masahide Motokawa

Subjects
Male, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Osteoclasts, General Biochemistry, Genetics and Molecular Biology, Mice, Insulin-like growth factor, Osteogenesis, Internal medicine, medicine, Animals, Femur, Dosing, Insulin-Like Growth Factor I, Dose-Response Relationship, Drug, General Veterinary, business.industry, General Medicine, Stimulation, Chemical, Mice, Inbred C57BL, Endocrinology, Femoral bone, Female, Animal Science and Zoology, Bone Remodeling, business, Linear growth, Cell Division
Abstract

The time-dependent effects of daily dosing of IGF-I (1.21 mg/g) on the linear growth of the femur were investigated in mice. The femoral length and volume and the number of osteoclasts were significantly greater after IGF-I injection as compared to the non-injected control, suggesting that the IGF-I imbalance might cause a quick turnover cycle of the bone resulting in the altered femoral modeling.

Published
2002
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2. Effect of alendronate on osteoclast differentiation and bone volume in transplanted bone

Author

Junji Ohtani, Masahide Motokawa, Mao Shigekawa, Keisuke Tsutsui, Tadashi Fujita, Yuiko Tohma, C Tokimasa, Kaoru Tenjou, Shinya Kohno, Toshitsugu Kawata, Kazuo Tanne, Masato Kaku, and Akira Matsuki

Subjects
medicine.medical_specialty, Osteoclasts, Bone tissue, Ectopic bone formation, General Biochemistry, Genetics and Molecular Biology, Bone resorption, Mice, Osteoclast, Internal medicine, medicine, Animals, Bone Resorption, Inhibitory effect, Bone Transplantation, General Veterinary, Alendronate, business.industry, Histocytochemistry, Cell Differentiation, General Medicine, Resorption, Surgery, Endocrinology, medicine.anatomical_structure, Animal Science and Zoology, business, Bone volume, Bone structure
Abstract

Alendronate, one of the bisphosphonates, is known to have an inhibitory effect on bone resorption. The purpose of this study was to investigate the effects of alendronate on ectopic bone graft resorption and to determine the optimal dose in the mouse. The grafted bone in the control group disappeared due to resorption by osteoclasts within 5 weeks. In the experimental groups, the area of bone tissue decreased by only 20-40% at 5 weeks post-operatively. At 8 and 9 weeks after surgery, the decreased area of bone structure was significantly less in all the 10(-4) M injected alendronate-immersed groups than in the 10(-4) M non-injected alendronate-immersed. At 9 weeks after surgery, the number of osteoclasts were significantly less in the 10(-4) M injected alendronate-treated groups than in the 10(-4) M non-injected alendronate-treated groups. These results suggest that alendronate inhibits resorption of ectopic bone graft at concentrations of 10(-4) and 10(-6) M.

Published
2004

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