1. Igf1r signalling acts on the anagen-to-catagen transition in the hair cycle.
- Author
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Castela, Mathieu, Linay, Fabien, Roy, Edwige, Moguelet, Philippe, Xu, Jie, Holzenberger, Martin, Khosrotehrani, Kiarash, and Aractingi, Selim
- Subjects
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HAIR follicles , *GROWTH factors , *SOMATOMEDIN , *INSULIN-like growth factor receptors , *KERATIN - Abstract
Insulin-like growth factor 1 ( Igf1) is important for skin development and homoeostasis. However, overexpression and inactivation studies have produced variable findings regarding its role in hair follicle (HF) biology. Here, we studied a conditional and inducible knockout of the Igf1 receptor ( Igf1r) in keratin 15-expressing bulge cells. Deletion of Igf1r after the development of the skin appendages in K15- Igf1rKO mice showed no abnormalities in epidermal homoeostasis. Numbers of bulge cells were lower in K15- Igf1rKO mice than in controls, without consequences on wound healing, at least in young mice. K15- Igf1rKO HFs entered anagen phase earlier than controls and showed a delay in the anagen/catagen switch. The expression of Bmp-4 mRNA was inhibited in HFs from K15- Igf1rKO. MED1 transcription was impaired in the epidermis of K15- Igf1rKO mice. These findings suggest that Igf1r controls the hair cycle, partly through Bmp-4 activation. [ABSTRACT FROM AUTHOR]
- Published
- 2017
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