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Start Over Author "Brown, Peter" Journal experimental neurology
31 results on '"Brown, Peter"'

31. γ oscillations in the human basal ganglia.

Author

Jenkinson N, Kühn AA, and Brown P

Subjects
Animals, Humans, Parkinson Disease diagnosis, Basal Ganglia physiology, Brain Waves physiology, Parkinson Disease physiopathology
Abstract

Interest in beta activity in the basal ganglia has mushroomed since it was first identified in the subthalamic nucleus of patients with Parkinson's disease in Jonathan Dostrovsky's landmark paper (Levy et al., 2000). Here we consider a less explored phenomenon; namely gamma frequency synchronisation of neurons in the basal ganglia. Gamma oscillations have been reported in a distributed network involving the basal ganglia, thalamus and motor cortex, and have been described in a wide range of diseases as well as during increased arousal and voluntary movement. In Parkinson's disease, gamma activity is promoted by dopaminergic therapy. These features suggest that its elevation may be involved in the production of movement and this hypothesis is supported by the correlation between the amplitude of gamma activity and limb kinematics. Here we review these data, discuss the functional anatomy of gamma activity in basal ganglia and question how closely it relates to the coding of movement parameters., (Copyright © 2012 Elsevier Inc. All rights reserved.)

Published
2013
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