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Your search keyword '"Wang, Rong-Fu"' showing total 1 results
Start Over Author "Wang, Rong-Fu" Topic interferons Journal experimental parasitology
1 results on '"Wang, Rong-Fu"'

1. TgMAPK1 is a Toxoplasma gondii MAP kinase that hijacks host MKK3 signals to regulate virulence and interferon-γ-mediated nitric oxide production.

Author

Brumlik, Michael J., Pandeswara, Srilakshmi, Ludwig, Sara M., Jeansonne, Duane P., Lacey, Michelle R., Murthy, Kruthi, Daniel, Benjamin J., Wang, Rong-Fu, Thibodeaux, Suzanne R., Church, Kristina M., Hurez, Vincent, Kious, Mark J., Zhang, Bin, Alagbala, Adebusola, Xia, Xiaojun, and Curiel, Tyler J.

Subjects
*TOXOPLASMA gondii, *MITOGEN-activated protein kinases, *NITRIC oxide, *MICROBIAL virulence, *INTERFERONS, *PARASITOLOGY
Abstract

Highlights: [•] TgMAPK1 is a Toxoplasma gondii mitogen-activated protein kinase (MAPK). [•] It affects parasite proliferation in an IFN-γ, iNOS and MKK3-dependent manner. [•] Parasite tissue burden is regulated by TgMAPK1 expression in iNOS-replete tissues. [•] Thus TgMAPK1 ultimately affects virulence by manipulating host IFN-γ-mediated iNOS. [ABSTRACT FROM AUTHOR]

Published
2013
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