1. Femoral vascular conductance and peroneal muscle sympathetic nerve activity responses to acute epidural spinal cord stimulation in humans
- Author
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Seth W. Holwerda, Gary L. Pierce, Chandan G. Reddy, and Marshall T. Holland
- Subjects
Adult ,Epidural Space ,Male ,medicine.medical_specialty ,Sympathetic Nervous System ,Femoral artery ,Spinal cord stimulation ,030204 cardiovascular system & hematology ,Peroneal muscle ,Article ,03 medical and health sciences ,0302 clinical medicine ,medicine.artery ,Internal medicine ,medicine ,Humans ,Brachial artery ,Muscle, Skeletal ,Aged ,Spinal Cord Stimulation ,integumentary system ,Peripheral blood flow ,business.industry ,Sympathetic nerve activity ,Peroneal Nerve ,General Medicine ,Vascular conductance ,Middle Aged ,Femoral Artery ,nervous system ,Neuropathic pain ,Cardiology ,Female ,business ,tissues ,030217 neurology & neurosurgery - Abstract
NEW FINDINGS What is the central question of this research? Does acute spinal cord stimulation increase vascular conductance and decrease muscle sympathetic nerve activity in the lower limbs of humans? What is the main finding and its importance? Acute spinal cord stimulation led to a rapid rise in femoral vascular conductance, and peroneal muscle sympathetic nerve activity demonstrated a delayed reduction that was not associated with the initial increase in femoral vascular conductance. These findings suggest that neural mechanisms in addition to attenuated muscle sympathetic nerve activity might be involved in the initial increase in femoral vascular conductance during acute spinal cord stimulation. ABSTRACT Clinical cases have indicated an increase in peripheral blood flow after continuous epidural spinal cord stimulation (SCS) and that reduced muscle sympathetic nerve activity (MSNA) might be a potential mechanism. However, no studies in humans have directly examined the effects of acute SCS (
- Published
- 2018