1. Update on the epidemiology of carbapenemases in Latin America and the Caribbean
- Author
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German Esparza, Ana Cristina Gales, Tobias Manuel Appel, Juan-Carlos García-Betancur, Juan M Villalobos-Vindas, Silvio Vega, Gabriel Levy-Hara, Luis Bavestrello, Luis E. Cuellar, Duilio Nuñez, Wanda Cornistein, Paulo F Castañeda-Mendez, Maria V. Villegas, Villegas, María Virginia [0000-0003-1898-9067], and Garcia Betancur, Juan Carlos [0000-0003-3371-3384]
- Subjects
Acinetobacter baumannii ,0301 basic medicine ,Microbiology (medical) ,medicine.medical_specialty ,Latin Americans ,Carbapenem resistance ,030106 microbiology ,medicine.disease_cause ,Microbiology ,beta-Lactamases ,03 medical and health sciences ,0302 clinical medicine ,Bacterial Proteins ,Virology ,Enterobacterales ,Drug Resistance, Multiple, Bacterial ,Epidemiology ,Gram-Negative Bacteria ,polycyclic compounds ,medicine ,Humans ,030212 general & internal medicine ,biology ,Pseudomonas aeruginosa ,biochemical phenomena, metabolism, and nutrition ,Carbapenemases ,biology.organism_classification ,Carbapenem-resistant Enterobacterales (CRE) ,Anti-Bacterial Agents ,Klebsiella pneumoniae ,Infectious Diseases ,Geography ,Latin America ,Carbapenems ,Caribbean Region ,Gram-Negative Bacterial Infections - Abstract
Introduction: Carbapenemases are β-lactamases able to hydrolyze a wide range of β-lactam antibiotics, including carbapenems. Carbapenemase production in Enterobacterales, Pseudomonas aeruginosa, and Acinetobacter spp., with and without the co-expression of other β-lactamases is a serious public health threat. Carbapenemases belong to three main classes according to the Ambler classification: class A, class B, and class D. Areas covered: Carbapenemase-bearing pathogens are endemic in Latin America. In this review, we update the status of carbapenemases in Latin America and the Caribbean. Expert opinion: Understanding the current epidemiology of carbapenemases in Latin America and the Caribbean is of critical importance to improve infection control policies limiting the dissemination of multi-drug-resistant pathogens and in implementing appropriate antimicrobial therapy.
- Published
- 2020