1. Evidence that prehypertension is a risk factor for Type 2 diabetes
- Author
-
Ivar L. Frithsen and Charles J. Everett
- Subjects
Male ,medicine.medical_specialty ,Diabetes risk ,Type 2 diabetes ,Risk Assessment ,Severity of Illness Index ,Prehypertension ,Insulin resistance ,Diabetes mellitus ,Internal medicine ,Internal Medicine ,medicine ,Humans ,Risk factor ,Epidemiology/Health Services Research ,Aged ,Original Research ,business.industry ,Incidence ,Blood Pressure Determination ,General Medicine ,Middle Aged ,Reference Standards ,medicine.disease ,Causality ,Blood pressure ,Diabetes Mellitus, Type 2 ,Hypertension ,Physical therapy ,Female ,Metabolic syndrome ,Cardiology and Cardiovascular Medicine ,business ,Follow-Up Studies - Abstract
OBJECTIVE Prehypertension is associated with cardiovascular disease and insulin resistance. However, whether subjects with prehypertension have more diabetes risk is not known. We examine whether prehypertension is a risk factor for developing type 2 diabetes. RESEARCH DESIGN AND METHODS Incident diabetes was examined in nondiabetic normotensive participants in the San Antonio Heart Study (n = 2,767; aged 25–65 years; median follow-up 7.8 years). RESULTS Incident diabetes was 12.4% in subjects with prehypertension and 5.6% in subjects with normal blood pressure. The odds of incident diabetes were 2.21 greater for individuals with prehypertension than for those with normal blood pressure (95% CI 1.63–2.98) after adjusting for age, sex, and ethnicity. Prehypertension was not associated with incident diabetes after additional adjustment for BMI, impaired glucose tolerance, insulin resistance and secretion, and family history of diabetes (odds ratio 1.42 [95% CI 0.99–2.02]). CONCLUSIONS Subjects with prehypertension are at increased risk of diabetes. Much of this risk is explained by disorders related to the insulin resistance syndrome.
- Published
- 2010