1. LDL cholesterol: should guidelines include targets?
- Author
-
Banerjee S, Kahali D, Banerjee A, and Brilakis ES
- Subjects
- Humans, Anticholesteremic Agents therapeutic use, Cholesterol, LDL blood, Coronary Disease drug therapy, Hypercholesterolemia drug therapy, Practice Guidelines as Topic
- Abstract
Elevated low-density lipoprotein cholesterol (LDL-C) is associated with adverse cardiovascular outcomes. The strategy of target-based LDL-C lowering to reduce the risk of coronary heart disease and secondary event rates is now well established. However, the strategy for treating to a target LDL-C, and whether there is a lower threshold level for LDL-C continues to be debated. We present, and critically analyze the evidence for a target-based LDL-C lowering strategy, and the safety and efficacy of intensive plasma LDL-C-lowering with traditional, and novel LDL-lowering therapies below current guideline targets.
- Published
- 2014
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