1. The use of alvimopan for postoperative ileus in small and large bowel resections.
- Author
-
Brady JT, Dosokey EM, Crawshaw BP, Steele SR, and Delaney CP
- Subjects
- Administration, Oral, Gastrointestinal Agents administration & dosage, Gastrointestinal Agents adverse effects, Humans, Ileus etiology, Ileus metabolism, Ileus physiopathology, Intestine, Large metabolism, Intestine, Large physiopathology, Intestine, Small metabolism, Intestine, Small physiopathology, Narcotic Antagonists administration & dosage, Narcotic Antagonists adverse effects, Piperidines administration & dosage, Piperidines adverse effects, Receptors, Opioid, mu antagonists & inhibitors, Receptors, Opioid, mu metabolism, Recovery of Function, Risk Factors, Treatment Outcome, Digestive System Surgical Procedures adverse effects, Gastrointestinal Agents therapeutic use, Ileus drug therapy, Intestine, Large drug effects, Intestine, Large surgery, Intestine, Small drug effects, Intestine, Small surgery, Narcotic Antagonists therapeutic use, Piperidines therapeutic use
- Abstract
Transient ileus is a normal physiologic process after surgery. When prolonged, it is an important contributor to postoperative complications, increased length of stay and increased healthcare costs. Efforts have been made to prevent and manage postoperative ileus; alvimopan is an oral, peripheral μ-opioid receptor antagonist, and the only currently US FDA-approved medication to accelerate the return of gastrointestinal function postoperatively.
- Published
- 2015
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