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PurposeTo assess ocular and systemic factors associated with diabetes mellitus in the adult population in rural and urban China.MethodsThe Beijing Eye Study 2006, a population-based, cross-sectional cohort study, included 3251 subjects aged 45 years and more (participation rate: 73.2%). Blood samples were available for 2960 (91.0%) subjects. Diabetes mellitus was defined by a fasting plasma glucose concentration ≥7.0 mmol/l or by a self-reported history diagnosis of diabetes.ResultsDiabetes mellitus was found in 381 (12.9%) subjects. In binary regression analysis, the presence of diabetes mellitus was significantly associated with body mass index, systolic blood pressure, triglyceride concentrations, intraocular pressure, cylindrical refractive dioptre, presence of arteriolar sheathing, rural vsurban region, lower best-corrected visual acuity, lower high-density lipoprotein level, and lower diastolic blood pressure. It was not statistically associated with age, presence of cataract (nuclear, cortical, or subcapsular), size of the optic disc, neuroretinal rim, αzone and βzone of peripapillary atrophy, retinal artery and vein diameters, arteriovenous nicking, focal or general narrowing, refractive error, prevalence of glaucoma, and early or late stage of age-related macular degeneration.ConclusionsIn a population-based setting, diabetes mellitus was not associated with optic disc, rim and peripapillary atrophy measurements, retinal vessel diameters, arteriovenous nicking, focal or general retinal artery narrowing, and prevalence of age-related macular degeneration. Although diabetes mellitus was significantly correlated with higher intraocular pressure, it was not associated with glaucoma.Eye (2009) 23, 676–682; doi:10.1038/sj.eye.6703104; published online 8 February 2008 [ABSTRACT FROM AUTHOR]

PurposeTo assess the relationship between glaucoma and mortality in a population-based setting.MethodsAt baseline in 2001, the Beijing Eye Study examined 4356 subjects for glaucoma with a detected glaucoma frequency of 135/4356 or 3.1%. Mean age was 55.9±10.4 years (40–101 years). In 2006, all study participants were reinvited for a follow-up examination.ResultsOut of the 4356 subjects, 3208 (73.6%) subjects returned for follow-up examination, while 124 (2.8%) subjects were dead, and 1024 (23.5%) subjects did not agree to be re-examined or had moved away. Mortality rate was significantly (P<0.001; odds ratio (OR): 4.72; 95% confidence interval (CI): 2.67, 8.33) higher in the 135 glaucoma subjects (15/135 or 11.1±2.7%; 95% CI: 5.8, 16.4) than in the 4221 participants without glaucoma (109/4221 or 2.6±0.2%; 95% CI: 2.2, 3.0). In binary logistic regression analysis, mortality was significantly associated with age (P<0.001), gender (P<0.001; OR: 0.44; 95% CI: 0.29, 0.66), level of education (P<0.001; OR: 0.64; 95% CI: 0.55, 0.74), and the presence of glaucoma (P=0.007; OR: 2.30; 95% CI: 1.26, 4.20). If the whole glaucoma group was differentiated into an open-angle glaucoma group and an angle-closure group, mortality was still significantly associated with age (P<0.001), gender (P<0.001), level of education (P<0.001), and with the presence of angle-closure glaucoma (P=0.006; OR: 3.09; 95% CI: 1.49, 10.2), while the association with the presence of open-angle glaucoma was marginally significant (P=0.13; OR: 1.83; 95% CI: 0.84, 4.01).ConclusionsThe data suggest that glaucoma, particularly angle-closure glaucoma, may be associated with an increased rate of mortality in adult Chinese in Greater Beijing.Eye (2008) 22, 434–438; doi:10.1038/sj.eye.6703072; published online 11 January 2008 [ABSTRACT FROM AUTHOR]

PurposeIThe purpose of the study was to examine a relationship between ocular perfusion pressure and open-angle glaucoma in a population-based setting in China.MethodsThe Beijing Eye Study 2006 is a population-based investigation, which included 3251 subjects (response rate: 73.2%). Mean age was 60.4±10.0 years (range, 45–89 years). Glaucoma was defined by a glaucomatous appearance of the optic disc.ResultsNeither in univariate nor in multivariate statistical analysis, systolic blood pressure, diastolic blood pressure, mean blood pressure, and ocular perfusion pressure were significantly associated with the prevalence of open-angle glaucoma. It also holds true if the whole glaucoma group was differentiated into a normal-pressure glaucoma group and a high-pressure glaucoma group.ConclusionsIn contrast to earlier population-based studies on western societies, the prevalence of open-glaucoma (also when differentiated into normal-pressure and high-pressure glaucomas) was not associated with the ocular perfusion pressure. The reasons for the discrepancy may be that most of the glaucoma patients in this study were untreated; that more than 80% of the glaucoma subjects of the present investigation had an intraocular pressure measurement <22 mmHg; and differences in the definition of glaucoma.Eye (2009) 23, 734–736; doi:10.1038/eye.2008.342; published online 7 November 2008 [ABSTRACT FROM AUTHOR]

BackgroundTo assess the relationship between peripheral anterior chamber depth and anthropomorphic measurements.MethodsThe Beijing Eye Study 2006 included 3251 (73.2%) subjects who returned for a follow-up examination after a baseline examination including 4335 subjects in 2001. The peripheral anterior chamber depth was estimated by slit lamp-assisted biomicroscopy using van Herick's method. Measurements of the body height and weight and assessment of the anterior chamber as inclusion criterion for this study were available for 3191 (98.2%) subjects.ResultsIn a multivariate analysis, a shallow peripheral anterior chamber was significantly associated with higher age (P<0.001), female gender (P<0.001), and shorter height (P<0.001), whereas weight (P=0.97) and body mass index (P=0.82) were not significantly associated.ConclusionsThe peripheral anterior chamber depth was inversely correlated with height, ie, a shallow peripheral anterior chamber may be expected with a higher frequency in short subjects than in tall subjects. Height, in addition to higher age and female gender, may be taken as one of the parameters for screening of subjects being at risk for primary angle-closure glaucoma.Eye (2009) 23, 632–634; doi:10.1038/eye.2008.26; published online 29 February 2008 [ABSTRACT FROM AUTHOR]